Adams S, Leblanc P, Datta SK (1991) Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens. Proc Nat Acad Sci USA 88:11271–11275
Bassing CH, Alt FW, Hughes MM, D’Auteuil M, Wehrly TD, Woodman BB, Gartner F, White JM, Davidson L, Sleckman BP (2000) Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature 405:583–586
Article CAS PubMed Google Scholar
Cibotti R, Cabaniols JP, Pannetier C, Delarbre C, Vergnon I, Kanellopoulos JM, Kourilsky P (1994) Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice. J Exp Med 180:861–872
Ippolito GC, Schelonka RL, Zemlin M, Ivanov II, Kobayashi R, Zemlin C, Gartland GL, Nitschke L, Pelkonen J, Fujihashi K, Rajewsky K, Schroeder HW Jr (2006) Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. J Exp Med 203:1567–1578
Article CAS PubMed PubMed Central Google Scholar
Irla M (2022) Instructive Cues of Thymic T Cell Selection. Annu Rev Immunol 40:95–119
Ivanov II, Schelonka RL, Zhuang Y, Gartland GL, Zemlin M, Schroeder HW Jr (2005) Development of the expressed immunoglobulin CDR-H3 repertoire is marked by focusing of constraints in length, amino acid utilization, and charge that are first established in early B cell progenitors. J Immunol 174:7773–7780
Article CAS PubMed Google Scholar
Jorgensen JL, Reay PA, Ehrich EW, Davis MM (1992) Molecular components of T-cell recognition. Annu Rev Immunol 10:835–873
Article CAS PubMed Google Scholar
Khass M, Vale AM, Burrows PD, Schroeder HW Jr (2018) The sequences of immunoglobulin diversity (DH) gene segments play key roles in controlling B cell development, antigen binding site diversity, and antibody production. Immunol Rev 284:106–119
Article CAS PubMed Google Scholar
Klein L, Kyewski B, Allen PM, Hogquist KA (2014) Positive and negative selection of the T cell repertoire: what thymocytes see (and don’t see). Nat Rev Immunol 14:377–391
Article CAS PubMed PubMed Central Google Scholar
Kyte J, Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157:105–132
Article CAS PubMed Google Scholar
Lefranc MP (2002) IMGT, the international ImMunoGeneTics database: a high-quality information system for comparative immunogenetics and immunology. Dev Comp Immunol 26:697–705
Article CAS PubMed Google Scholar
Levinson M, Khass M, Burrows PD, Schroeder Jr HW (2020) Replacement of TCR Dbeta With Immunoglobulin DH DSP2.3 Imposes a Tyrosine-Enriched TCR Repertoire and Adversely Affects T Cell Development. Front Immunol 11:573413
Levinson M, Schelonka RL, Silva-Sanchez A, Kapoor P, Burrows PD, Schroeder HWJ (2018) Substituting an immunoglobulin DH for TCR Db1 alters T cell repertoire development and function. Univ Alabama Birmingham
Ma L, Yang L, Shi B, He X, Peng A, Li Y, Zhang T, Sun S, Ma R, Yao X (2016) Analyzing the CDR3 repertoire with the respect to TCR-Beta chain and V-D-J and V-J rearrangements in peripheral T cells using HTS. Sci Rep 6
Madi A, Shifrut E, Reich-Zeliger S, Gal H, Best K, Ndifon W, Chain B, Cohen IR, Friedman N (2014) T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity. Genome Res 24:1603–1612
Article CAS PubMed PubMed Central Google Scholar
Mathieu N, Hempel WM, Spicuglia S, Verthuy C, Ferrier P (2000) Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: implications for the control of TCR-beta locus recombination. J Exp Med 192:625–636
Article CAS PubMed PubMed Central Google Scholar
Nguyen HH, Zemlin M, Vu HL, Ivanov II, Andrasi J, Zemlin C, Schelonka RL, Schroeder HW Jr, Mestecky J (2007) Heterosubtypic immunity to influenza A virus infection requires a properly diversified antibody repertoire. J Virol 81:9331–9338
Article CAS PubMed PubMed Central Google Scholar
Noonan DJ, Kofler R, Singer PA, Cardenas G, Dixon FJ, Theofilopoulos AN (1986) Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity. J Exp Med 163:644–653
Article CAS PubMed Google Scholar
Ou JWS, Brodsky MH, Zhu LJ (2018) motifStack for the analysis of transcription factor binding site evolution. Nat Methods 15:8–9
Article CAS PubMed Google Scholar
Rajewsky K (1996) Clonal selection and learning in the antibody system. Nature 381:751–758
Article CAS PubMed Google Scholar
Shah DK, Zuniga-Pflucker JC (2014) An overview of the intrathymic intricacies of T cell development. J Immunol 192:4017–4023
Article CAS PubMed Google Scholar
Teague TK, Tan C, Marino JH, Davis BK, Taylor AA, Huey RW, Van De Wiele CJ (2010) CD28 expression redefines thymocyte development during the pre-T to DP transition. Int Immunol 22:387–397
Article CAS PubMed Google Scholar
Vale AM, Kapoor P, Skibinski GA, Elgavish A, Mahmoud TI, Zemlin C, Zemlin M, Burrows PD, Nobrega A, Kearney JF, Briles DE, Schroeder HW Jr (2013) The link between antibodies to OxLDL and natural protection against pneumococci depends on DH gene conservation. J Exp Med 210:875–890
Article CAS PubMed PubMed Central Google Scholar
Wang C, Sanders CM, Yang Q, Schroeder HW Jr, Wang E, Babrzadeh F, Gharizadeh B, Myers RM, Hudson JR Jr, Davis RW, Han J (2010) High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets. Proc Natl Acad Sci USA 107:1518–1523
Article CAS PubMed PubMed Central Google Scholar
Yoshida RYTYSMTT-MTTYSR (2000) A new method for quantitative analysis of the mouse T-cell receptor V region repertoires: comparison of repertoires among strains. Immunogenetics 53:35–45
Zemlin M, Schelonka RL, Ippolito GC, Nitschke L, Pelkonen J, Rajewsky K, Schroeder Jr HW (2007) Forced use of DH RF2 sequence impairs B cell development. In Kalil J, Cunha-Neto E, Rizzo LV (eds.) 13th International Congress of Immunology. Medimond Intern Proc Bologna
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