Samuel C, Cornman H, Kambala A, Kwatra SG. A review on the safety of using JAK inhibitors in dermatology: clinical and laboratory monitoring. Dermatol Ther (Heidelb). 2023;13:729–49. https://doi.org/10.1007/s13555-023-00892-5.
Article PubMed PubMed Central Google Scholar
Damsky W, King BA. JAK inhibitors in dermatology: the promise of a new drug class. J Am Acad Dermatol. 2017;76:736–44. https://doi.org/10.1016/j.jaad.2016.12.005.
Article CAS PubMed PubMed Central Google Scholar
Schwartz DM, Bonelli M, Gadina M, O’Shea JJ. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat Rev Rheumatol. 2016;12:25–36. https://doi.org/10.1038/nrrheum.2015.167.
Article CAS PubMed Google Scholar
Smolen JS, Pangan AL, Emery P, Rigby W, Tanaka Y, Vargas JI, et al. Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study. Lancet. 2019;393:2303–11. https://doi.org/10.1016/S0140-6736(19)30419-2.
Van Der Heijde D, Song I-H, Pangan AL, Deodhar A, Van Den Bosch F, Maksymowych WP, et al. Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial. Lancet. 2019;394:2108–17. https://doi.org/10.1016/S0140-6736(19)32534-6.
Sandborn WJ, Feagan BG, Loftus EV, Peyrin-Biroulet L, Van Assche G, D’Haens G, et al. Efficacy and safety of upadacitinib in a randomized trial of patients with Crohn’s disease. Gastroenterology. 2020;158:2123-8.e8. https://doi.org/10.1053/j.gastro.2020.01.047.
Article CAS PubMed Google Scholar
Levy G, Guglielmelli P, Langmuir P, Constantinescu SN. JAK inhibitors and COVID-19. J Immunother Cancer. 2022;10:e002838. https://doi.org/10.1136/jitc-2021-002838.
Article PubMed PubMed Central Google Scholar
McInnes IB, Anderson JK, Magrey M, Merola JF, Liu Y, Kishimoto M, et al. Trial of upadacitinib and adalimumab for psoriatic arthritis. N Engl J Med. 2021;384:1227–39. https://doi.org/10.1056/NEJMoa2022516.
Article CAS PubMed Google Scholar
Yang F, Lu C, Wang Y, Liu H, Leng X, Zeng X. Efficacy and safety of Janus kinase inhibitors in patients with psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Clin Rheumatol. 2023;42:1593–605. https://doi.org/10.1007/s10067-023-06529-4.
Olivera PA, Lasa JS, Bonovas S, Danese S, Peyrin-Biroulet L. Safety of Janus kinase inhibitors in patients with inflammatory bowel diseases or other immune-mediated diseases: a systematic review and meta-analysis. Gastroenterology. 2020;158:1554-73.e12. https://doi.org/10.1053/j.gastro.2020.01.001.
Article CAS PubMed Google Scholar
King B, Senna MM, Mesinkovska NA, Lynde C, Zirwas M, Maari C, et al. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: results from the phase 3 randomized, controlled trial (THRIVE-AA1). J Am Acad Dermatol. 2024;91:880–8. https://doi.org/10.1016/j.jaad.2024.06.097.
Article CAS PubMed Google Scholar
King B, Soung J, Tziotzios C, Rudnicka L, Joly P, Gooderham M, et al. Integrated safety analysis of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, for the treatment of alopecia areata from the ALLEGRO clinical trial program. Am J Clin Dermatol. 2024;25:299–314. https://doi.org/10.1007/s40257-024-00846-3.
Article PubMed PubMed Central Google Scholar
Kwon O, Senna MM, Sinclair R, Ito T, Dutronc Y, Lin C-Y, et al. Efficacy and safety of baricitinib in patients with severe alopecia areata over 52 weeks of continuous therapy in two phase III trials (BRAVE-AA1 and BRAVE-AA2). Am J Clin Dermatol. 2023;24:443–51. https://doi.org/10.1007/s40257-023-00764-w.
Article PubMed PubMed Central Google Scholar
Paller AS, Ladizinski B, Mendes-Bastos P, Siegfried E, Soong W, Prajapati VH, et al. Efficacy and safety of upadacitinib treatment in adolescents with moderate-to-severe atopic dermatitis: analysis of the Measure Up 1, Measure Up 2, and AD Up randomized clinical trials. JAMA Dermatol. 2023;159:526. https://doi.org/10.1001/jamadermatol.2023.0391.
Article PubMed PubMed Central Google Scholar
Reich K, Teixeira HD, De Bruin-Weller M, Bieber T, Soong W, Kabashima K, et al. Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2021;397:2169–81. https://doi.org/10.1016/S0140-6736(21)00589-4.
Article CAS PubMed Google Scholar
Li C, Li Z, Cao Y, Li L, Li F, Li Y, et al. Tofacitinib for the treatment of nail lesions and palmoplantar pustulosis in synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome. JAMA Dermatol. 2021;157:74. https://doi.org/10.1001/jamadermatol.2020.3095.
Article PubMed PubMed Central Google Scholar
Rosmarin D, Passeron T, Pandya AG, Grimes P, Harris JE, Desai SR, et al. Two phase 3, randomized, controlled trials of ruxolitinib cream for vitiligo. N Engl J Med. 2022;387:1445–55. https://doi.org/10.1056/NEJMoa2118828.
Article CAS PubMed Google Scholar
Elmariah SB, Smith JS, Merola JF. JAK in the [black] box: a dermatology perspective on systemic JAK inhibitor safety. Am J Clin Dermatol. 2022;23:427–31. https://doi.org/10.1007/s40257-022-00701-3.
Reich K, Kabashima K, Peris K, Silverberg JI, Eichenfield LF, Bieber T, et al. Efficacy and safety of baricitinib combined with topical corticosteroids for treatment of moderate to severe atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2020;156:1333. https://doi.org/10.1001/jamadermatol.2020.3260.
Article PubMed PubMed Central Google Scholar
Piraccini BM, Cedirian S, Pampaloni F, Rapparini L, Quadrelli F, Bruni F, et al. Effectiveness and safety of baricitinib in severe alopecia areata: 48‐week results. Acad Dermatol Venereol. 2025. https://doi.org/10.1111/jdv.70067.
Piraccini BM, Pampaloni F, Cedirian S, Quadrelli F, Bruni F, Rapparini L, et al. Real-life effectiveness and safety of baricitinib in patients with severe alopecia areata: a 24-week Italian study. J Eur Acad Dermatol Venereol. 2025;39:1143–51. https://doi.org/10.1111/jdv.20312.
Article CAS PubMed Google Scholar
Starace M, Pampaloni F, Quadrelli F, Olivoni G, Cedirian S, Rapparini L, et al. Effectiveness of baricitinib on nail alopecia areata: a 48-week single-center retrospective study. Clin Drug Investig. 2026;46(4):447–53. https://doi.org/10.1007/s40261-026-01533-3.
Article CAS PubMed Google Scholar
Guo L, Feng S, Sun B, Jiang X, Liu Y. Benefit and risk profile of tofacitinib for the treatment of alopecia areata: a systemic review and meta‐analysis. Acad Dermatol Venereol. 2020;34:192–201. https://doi.org/10.1111/jdv.15937.
Sechi A, Song J, Dell’Antonia M, Heidemeyer K, Piraccini BM, Starace M, et al. Adverse events in patients treated with Jak-inhibitors for alopecia areata: a systematic review. J Eur Acad Dermatol Venereol. 2024. https://doi.org/10.1111/jdv.19090. (Online ahead of print).
Yoon S, Kim K, Shin K, Kim H-S, Kim B, Kim M-B, et al. The safety of systemic janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials. J Eur Acad Dermatol Venereol. 2024;38:52–61. https://doi.org/10.1111/jdv.19426.
Article CAS PubMed Google Scholar
Simpson EL, Sinclair R, Forman S, Wollenberg A, Aschoff R, Cork M, et al. Efficacy and safety of abrocitinib in adults and adolescents with moderate-to-severe atopic dermatitis (JADE MONO-1): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial. Lancet. 2020;396:255–66. https://doi.org/10.1016/S0140-6736(20)30732-7.
Article CAS PubMed Google Scholar
Rønnstad ATM, Isufi D, Bunick CG, Chovatiya R, Nielsen M-L, Alinaghi F, et al. Real-world evidence of effectiveness and safety of abrocitinib, baricitinib and uadacitinib in atopic dermatitis: a systematic review and meta-analysis. Am J Clin Dermatol. 2025;26(3):411–24. https://doi.org/10.1007/s40257-025-00997-x.
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