The demand for sustainable and environmentally friendly chemical processes has led to the development of innovative catalytic systems and solvent designs. Herein, we report a novel approach utilizing ruthenium catalysis in deep eutectic solvents (DES) for the selective alkynylation of C-H bonds. Ruthenium, known for its low toxicity and cost-effectiveness, serves as an excellent alternative to other transition metals in eutectic liquids. Moreover, the utilization of supramolecular -cyclodextrin-based deep eutectic liquids enhances the eco-friendliness and recoverability of the solvent system. The late-stage functionalization of drugs exemplifies the practical applicability and versatility of this method in organic synthesis, offering a sustainable pathway towards the synthesis of valuable compounds.

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