Brain structural correlates of an impending initial major depressive episode

Schmaal L, Veltman DJ, van Erp TGM, Sämann PG, Frodl T, Jahanshad N, et al. Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group. Mol Psychiatry. 2016;21:806–12.

Article  PubMed  CAS  Google Scholar 

Schmaal L, Hibar DP, Sämann PG, Hall GB, Baune BT, Jahanshad N, et al. Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group. Mol Psychiatry. 2017;22:900–9.

Article  PubMed  CAS  Google Scholar 

Gray JP, Müller VI, Eickhoff SB, Fox PT. Multimodal abnormalities of brain structure and function in major depressive disorder: a meta-analysis of neuroimaging studies. AJP. 2020;177:422–34.

Article  Google Scholar 

Hare BD, Duman RS. Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions. Mol Psychiatry. 2020;25:2742–58.

Article  PubMed  PubMed Central  Google Scholar 

Kebets V, Favre P, Houenou J, Polosan M, Perroud N, Aubry J-M, et al. Fronto-limbic neural variability as a transdiagnostic correlate of emotion dysregulation. Transl Psychiatry. 2021;11:545.

Article  PubMed  PubMed Central  Google Scholar 

Bora E, Fornito A, Pantelis C, Yücel M. Gray matter abnormalities in Major Depressive Disorder: a meta-analysis of voxel based morphometry studies. J Affect Disord. 2012;138:9–18.

Article  PubMed  Google Scholar 

Dannlowski U, Winter NR, Meinert S, Grotegerd D, Kraus A, Flinkenflügel K, et al. Replicability and generalizability of gray matter reductions in major depression: a voxel-based investigation of 4021 individuals. Preprint at SSRN: https://ssrn.com/abstract=4854882 (2024).

McKinnon MC, Yucel K, Nazarov A, MacQueen GM. A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. J Psychiatry Neurosci. 2009;34:41–54.

PubMed  PubMed Central  Google Scholar 

Hamilton JP, Siemer M, Gotlib IH. Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Mol Psychiatry. 2008;13:993–1000.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nolan M, Roman E, Nasa A, Levins KJ, O’Hanlon E, O’Keane V, et al. Hippocampal and amygdalar volume changes in major depressive disorder: a targeted review and focus on stress. Chronic Stress. 2020;4:247054702094455.

Article  Google Scholar 

Zhang H, Li L, Wu M, Chen Z, Hu X, Chen Y, et al. Brain gray matter alterations in first episodes of depression: a meta-analysis of whole-brain studies. Neurosci Biobehav Rev. 2016;60:43–50.

Article  PubMed  Google Scholar 

Schmaal L, van Velzen LS. Deficits in white matter microstructure in major depressive disorder: cause, consequence, or correlate? Biol Psychiatry. 2019;86:734–5.

Article  PubMed  Google Scholar 

Kronenberg G, Tebartz Van Elst L, Regen F, Deuschle M, Heuser I, Colla M. Reduced amygdala volume in newly admitted psychiatric in-patients with unipolar major depression. J Psychiatr Res. 2009;43:1112–7.

Article  PubMed  Google Scholar 

Lemke H, Romankiewicz L, Förster K, Meinert S, Waltemate L, Fingas SM, et al. Association of disease course and brain structural alterations in major depressive disorder. Depression Anxiety. 2022;39:441–51.

Article  PubMed  Google Scholar 

Stratmann M, Konrad C, Kugel H, Krug A, Schöning S, Ohrmann P, et al. Insular and hippocampal gray matter volume reductions in patients with major depressive disorder. PLoS ONE. 2014;9:e102692.

Article  PubMed  PubMed Central  Google Scholar 

Treadway MT, Waskom ML, Dillon DG, Holmes AJ, Park MTM, Chakravarty MM, et al. Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression. Biol Psychiatry. 2015;77:285–94.

Article  PubMed  Google Scholar 

Lemke H, Klute H, Skupski J, Thiel K, Waltemate L, Winter A, et al. Brain structural correlates of recurrence following the first episode in patients with major depressive disorder. Transl Psychiatry. 2022;12:349.

Article  PubMed  PubMed Central  Google Scholar 

Phillips JL, Batten LA, Tremblay P, Aldosary F, Blier P. A prospective, longitudinal study of the effect of remission on cortical thickness and hippocampal volume in patients with treatment-resistant depression. Int J Neuropsychopharmacol. 2015;18:pyv037–pyv037.

Article  PubMed  PubMed Central  Google Scholar 

Zaremba D, Dohm K, Redlich R, Grotegerd D, Strojny R, Meinert S, et al. Association of brain cortical changes with relapse in patients with major depressive disorder. JAMA Psychiatry. 2018;75:484.

Article  PubMed  PubMed Central  Google Scholar 

Förster K, Grotegerd D, Dohm K, Lemke H, Enneking V, Meinert S, et al. Association of hospitalization with structural brain alterations in patients with affective disorders over nine years. Transl Psychiatry. 2023;13:170.

Article  PubMed  PubMed Central  Google Scholar 

Frodl T, Meisenzahl E, Zetzsche T, Bottlender R, Born C, Groll C, et al. Enlargement of the amygdala in patients with a first episode of major depression. Biol Psychiatry. 2002;51:708–14.

Article  PubMed  Google Scholar 

Van Eijndhoven P, Van Wingen G, Van Oijen K, Rijpkema M, Goraj B, Jan Verkes R, et al. Amygdala volume marks the acute state in the early course of depression. Biol Psychiatry. 2009;65:812–8.

Article  PubMed  Google Scholar 

Dohm K, Redlich R, Zwitserlood P, Dannlowski U. Trajectories of major depression disorders: a systematic review of longitudinal neuroimaging findings. Aust N. Z J Psychiatry. 2017;51:441–54.

Article  PubMed  Google Scholar 

Frodl TS, Koutsouleris N, Bottlender R, Born C, Jäger M, Scupin I, et al. Depression-related variation in brain morphology over 3 years: effects of stress? Arch Gen Psychiatry. 2008;65:1156.

Article  PubMed  Google Scholar 

Jones SA, Morales AM, Lavine JB, Nagel BJ. Convergent neurobiological predictors of emergent psychopathology during adolescence. Birth Defects Res. 2017;109:1613–22.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Toenders YJ, van Velzen LS, Heideman IZ, Harrison BJ, Davey CG, Schmaal L. Neuroimaging predictors of onset and course of depression in childhood and adolescence: A systematic review of longitudinal studies. Dev Cogn Neurosci. 2019;39:100700.

Article  PubMed  PubMed Central  Google Scholar 

Nickson T, Chan SWY, Papmeyer M, Romaniuk L, Macdonald A, Stewart T, et al. Prospective longitudinal voxel-based morphometry study of major depressive disorder in young individuals at high familial risk. Psychol Med. 2016;46:2351–61.

Article  PubMed  CAS  Google Scholar 

Whittle S, Lichter R, Dennison M, Vijayakumar N, Schwartz O, Byrne ML, et al. Structural brain development and depression onset during adolescence: a prospective longitudinal study. AJP. 2014;171:564–71.

Article  Google Scholar 

Ferrari AJ, Santomauro DF, Aali A, Abate YH, Abbafati C, Abbastabar H, et al. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403:2133–61.

Article  Google Scholar 

Kircher T, Wöhr M, Nenadic I, Schwarting R, Schratt G, Alferink J, et al. Neurobiology of the major psychoses: a translational perspective on brain structure and function—the FOR2107 consortium. Eur Arch Psychiatry Clin Neurosci. 2019;269:949–62.

Article  PubMed  Google Scholar 

Vogelbacher C, Möbius TWD, Sommer J, Schuster V, Dannlowski U, Kircher T, et al. The Marburg-Münster Affective Disorders Cohort Study (MACS): A quality assurance protocol for MR neuroimaging data. NeuroImage. 2018;172:450–60.

Article  PubMed  Google Scholar 

Wittchen HU, Wunderlich U, Grushwitz S, Zaudig M SKID I Strukturiertes Klinisches Interview für DSM-IV. Achse I: Psychische Störungen. Interviewheft und Beurteilungsheft. Eine Deutschsprachige, Erweiterte Bearbeitung Der Amerikanischen Originalversion Des SCID I. 1997.

Post RM, Roy-Byrne PP, Uhde TW. Graphic representation of the life course of illness in patients with affective disorder. AJP. 1988;145:844–8.

Article  CAS  Google Scholar 

Hamilton M. A Rating Scale For Depression. J Neurol, Neurosurg Psychiatry. 1960;23:56–62.

Article  PubMed  CAS  Google Scholar

Comments (0)

No login
gif