Douglawi, A. & Masterson, T. A. Updates on the epidemiology and risk factors for penile cancer. Transl. Androl. Urol. 6, 785–790 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Moore, T. O. et al. Human papillomavirus, smoking, and cancer. J. Cutan. Med. Surg. 5, 323–328 (2001).

Article  CAS  PubMed  Google Scholar 

Tsen, H. F., Morgenstern, H., Mack, T. & Peters, R. K. Risk factors for penile cancer: results of a population-based case-control study in Los Angeles County (United States). Cancer Causes Control 12, 267–277 (2001).

Article  CAS  PubMed  Google Scholar 

Do, H. T. T. et al. The etiologic role of human papillomavirus in penile cancers: a study in Vietnam. Br. J. Cancer 108, 229–233 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu, L. et al. Global pattern and trends in penile cancer incidence: population-based study. JMIR Public Health Surveill. 8, e34874 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Olesen, T. B. et al. Prevalence of human papillomavirus DNA and p16INK4a in penile cancer and penile intraepithelial neoplasia: a systematic review and meta-analysis. Lancet Oncol. 20, 145–158 (2019).

Article  CAS  PubMed  Google Scholar 

Wenzel, M. et al. Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma. Cancer Causes Control 33, 25–35 (2022).

Article  PubMed  Google Scholar 

Xu, L., Dahlstrom, K. R., Lairson, D. R. & Sturgis, E. M. Projected oropharyngeal carcinoma incidence among middle-aged US men. Head Neck 41, 3226–3234 (2019).

Article  PubMed  Google Scholar 

Bruni, L. et al. Global and regional estimates of genital human papillomavirus prevalence among men: a systematic review and meta-analysis. Lancet Glob. Health 11, e1345–e1362 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vieira, C. B. et al. Profile of patients with penile cancer in the region with the highest worldwide incidence. Sci. Rep. 10, 2965 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brouwer, O. R. et al. European Association of Urology-American Society of Clinical Oncology Collaborative Guideline on Penile Cancer: 2023 Update. Eur. Urol. 83, 548–560 (2023).

Article  PubMed  Google Scholar 

Tomas, Anita et al. Penile cancer. Nat. Rev. Dis. Primers 7, 11 (2021). This comprehensive primer provides essential insights into the epidemiology, pathology and management strategies for penile cancer, highlighting the need for increased awareness and improved treatment protocols in this rare malignancy.

Article  Google Scholar 

Schlenker, B. & Schneede, P. The role of human papilloma virus in penile cancer prevention and new therapeutic agents. Eur. Urol. Focus 5, 42–45 (2019). The study emphasizes the association between HPV and penile cancer, advocating for preventive measures and innovative therapeutic approaches to mitigate this risk.

Article  PubMed  Google Scholar 

Deng, X. et al. Trends in incidence, mortality, and survival of penile cancer in the United States: a population-based study. Front. Oncol. 12, 891623 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Djajadiningrat, R. S. et al. Contemporary management of regional nodes in penile cancer — improvement of survival? J. Urol. 191, 68–73 (2014).

Article  PubMed  Google Scholar 

Muneer, A. et al. Penile cancer: ESMO–EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up. ESMO Open 9, 103481 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bandini, M., Pederzoli, F. & Necchi, A. Neoadjuvant chemotherapy for lymph node-positive penile cancer: current evidence and knowledge. Curr. Opin. Urol. 30, 218–222 (2020).

Article  PubMed  Google Scholar 

Chipollini, J., Necchi, A. & Spiess, P. E. Outcomes for patients with node-positive penile cancer: impact of perioperative systemic therapies and the importance of surgical intervention. Eur. Urol. 74, 241–242 (2018).

Article  PubMed  Google Scholar 

Tang, Y., Hu, X., Wu, K. & Li, X. Immune landscape and immunotherapy for penile cancer. Front. Immunol. 13, 1055235 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cleary, C. et al. Biological features of human papillomavirus-related head and neck cancers contributing to improved response. Clin. Oncol. 28, 467–474 (2016).

Article  CAS  Google Scholar 

van Kempen, P. M. W. et al. Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma: a systematic review. Epigenetics 9, 194–203 (2014).

Article  PubMed  Google Scholar 

McBride, A. A. Human papillomaviruses: diversity, infection and host interactions. Nat. Rev. Microbiol. 20, 95–108 (2022). The complexity of HPVs, their diverse interactions with hosts and their implications for diseases such as penile cancer are discussed in this review, underscoring the importance of understanding HPV biology for effective prevention strategies.

Article  CAS  PubMed  Google Scholar 

Van Doorslaer, K. Evolution of the papillomaviridae. Virology 445, 11–20 (2013).

Article  PubMed  Google Scholar 

Moscicki, A.-B. et al. Updating the natural history of human papillomavirus and anogenital cancers. Vaccine 30, F24–F33 (2012).

Article  PubMed  PubMed Central  Google Scholar 

de Martel, C., Plummer, M., Vignat, J. & Franceschi, S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int. J. Cancer 141, 664–670 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Doorbar, J., Egawa, N., Griffin, H., Kranjec, C. & Murakami, I. Human papillomavirus molecular biology and disease association. Rev. Med. Virol. 25, 2–23 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mittal, S. & Banks, L. Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation. Mutat. Res. Rev. Mutat. Res. 772, 23–35 (2017).

Article  CAS  PubMed  Google Scholar 

Nazha, B. et al. Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune-checkpoint inhibitor-related biomarkers. Cancer 129, 3884–3893 (2023).

Article  CAS  PubMed  Google Scholar 

Martinez-Zapien, D. et al. Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. Nature 529, 541–545 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elst, L. et al. Single-cell atlas of penile cancer reveals TP53 mutations as a driver of an aggressive phenotype, irrespective of human papillomavirus status, and provides clues for treatment personalization. Eur. Urol. S0302-2838, 02266–02268 (2024).

Google Scholar 

DiGiuseppe, S., Bienkowska-Haba, M., Guion, L. G. M., Keiffer, T. R. & Sapp, M. Human papillomavirus major capsid protein L1 remains associated with the incoming viral genome throughout the entry process. J. Virol. 91, e00537–17 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferreira, A. R., Ramalho, A. C., Marques, M. & Ribeiro, D. The interplay between antiviral signalling and carcinogenesis in human papillomavirus infections. Cancers 12, 646 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Florin, L., Schäfer, F., Sotlar, K., Streeck, R. E. & Sapp, M. Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2. Virology 295, 97–107 (2002).