Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81:646–56.
PubMed PubMed Central Google Scholar
Glyn-Jones S, Palmer A. Osteoarthritis. Lancet. 2015;386:376–87.
Article CAS PubMed Google Scholar
Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum. 2001;44:1237–47.
Heiden TL, Lloyd DG, Ackland TR. Knee extension and flexion weakness in people with knee osteoarthritis: is antagonist cocontraction a factor? J Orthop Sports Phys Ther. 2009;39:807–15.
Wang M, Li S, Zhang L, Tian J, Ma J, Lei B, et al. Injectable bioactive antioxidative one-component polycitrate hydrogel with anti-inflammatory effects for osteoarthritis alleviation and cartilage protection. Adv Healthc Mater. 2024;13:e2301953.
Hunter DJ, Guermazi A, Roemer F, Zhang Y, Neogi T. Structural correlates of pain in joints with osteoarthritis. Osteoarthritis Cartilage. 2013;21:1170-8.
Targońska-Stępniak B. Osteoarthritis as an inflammatory disease. Ból. 2020;20:35–40.
Kuppa SS, Kim HK, Kang JY, Lee SC, Seon JK. Role of mesenchymal stem cells and their paracrine mediators in macrophage polarization: an approach to reduce inflammation in osteoarthritis. Int J Mol Sci. 2022;23:13016.
Olivotto E, Otero M, Marcu KB, Goldring MB. Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation. RMD Open. 2015;1:e000061.
Attur M, Belitskaya-Lévy I, Oh C, Krasnokutsky S, Greenberg J, Samuels J, et al. Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum. 2011;63:1908–17.
Jacobs HN, Rathod S, Wolf MT, Elisseeff JH. Intra-articular injection of urinary bladder matrix reduces osteoarthritis development. AAPS J. 2017;19:141–9.
Kuppa SS, Kim HK, Kang JY, Lee SC, Yang HY, Sankaranarayanan J, et al. Polynucleotides suppress inflammation and stimulate matrix synthesis in an in vitro cell-based osteoarthritis model. Int J Mol Sci. 2023;24:12282.
Bacchi S, Palumbo P, Sponta A, Coppolino MF. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. Antiinflamm Antiallergy Agents Med Chem. 2012;11:52–64.
Argoff C. Mechanisms of pain transmission and pharmacologic management. Curr Med Res Opin. 2011;27:2019–31.
Article CAS PubMed Google Scholar
Billesberger LM, Fisher KM, Qadri YJ, Boortz-Marx RL. Procedural treatments for knee osteoarthritis: a review of current injectable therapies. Pain Res Manag. 2020;2020:3873098.
Bjarnason I. Gastrointestinal safety of NSAIDs and over-the-counter analgesics. Int J Clin Pract Suppl. 2013;178:37–42.
Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol. 2020;180:114147.
Article CAS PubMed PubMed Central Google Scholar
Bryant SJ, Anseth KS. Hydrogel properties influence ECM production by chondrocytes photoencapsulated in poly(ethylene glycol) hydrogels. J Biomed Mater Res. 2002;59:63–72.
Liang J, Liu P, Yang X, Liu L, Zhang Y, Wang Q, et al. Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications. J Orthop Translat. 2023;41:54–62.
Wang B, Chariyev-Prinz F, Burdis R, Eichholz K, Kelly DJ. Additive manufacturing of cartilage-mimetic scaffolds as off-the-shelf implants for joint regeneration. Biofabrication. 2022;14:024101.
Shalumon KT, Chen JP. Scaffold-based drug delivery for cartilage tissue regeneration. Curr Pharm Des. 2015;21:1979–90.
Article CAS PubMed Google Scholar
Choi BH, Choi KH, Lee HS, Song BR, Park SR, Yang JW, et al. Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix. Biomaterials. 2014;35:5711–20.
Article CAS PubMed Google Scholar
Robbins SL, Kumar V. Robbins and Cotran pathologic basis of disease. 8th edition. Philadelphia: Elsevier Saunders; 2010.
Gao Y, Liu S, Huang J, Guo W, Chen J, Zhang L, et al. The ECM-cell interaction of cartilage extracellular matrix on chondrocytes. Biomed Res Int. 2014:2014:648459.
Kim HJ, Lee S, Yun HW, Yin XY, Kim SH, Choi BH, et al. In vivo degradation profile of porcine cartilage-derived extracellular matrix powder scaffolds using a non-invasive fluorescence imaging method. J Biomater Sci Polym Ed. 2016;27:177–90.
Yin H, Wang Y, Sun X, Cui G, Sun Z, Chen P, et al. Functional tissue-engineered microtissue derived from cartilage extracellular matrix for articular cartilage regeneration. Acta Biomater. 2018;77:127–41.
Article CAS PubMed Google Scholar
Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, et al. Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res. 2016;34:995–1003.
Article CAS PubMed Google Scholar
Li Y, Cao J, Han S, Liang Y, Zhang T, Zhao H, et al. ECM based injectable thermo-sensitive hydrogel on the recovery of injured cartilage induced by osteoarthritis. Artif Cell Nanomed Biotechnol. 2018;46:152–60.
Cheng NC, Estes BT, Awad HA, Guilak F. Chondrogenic differentiation of adipose-derived adult stem cells by a porous scaffold derived from native articular cartilage extracellular matrix. Tissue Eng Part A. 2009;15:231–41.
Yang Q, Peng J, Guo Q, Huang J, Zhang L, Yao J, et al. A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled chondrogenic bone marrow-derived mesenchymal stem cells. Biomaterials. 2008;29:2378–87.
Giarratana LS, Marelli BM, Crapanzano C, De Martinis SE, Gala L, Ferraro M, et al. A randomized double-blind clinical trial on the treatment of knee osteoarthritis: the efficacy of polynucleotides compared to standard hyaluronian viscosupplementation. Knee. 2014;21:661–8.
Vanelli R, Costa P, Rossi SM, Benazzo F. Efficacy of intra-articular polynucleotides in the treatment of knee osteoarthritis: a randomized, double-blind clinical trial. Knee Surg Sports Traumatol Arthrosc. 2010;18:901–7.
Rothrauff BB, Yang G, Tuan RS. Tissue-specific bioactivity of soluble tendon-derived and cartilage-derived extracellular matrices on adult mesenchymal stem cells. Stem Cell Res Ther. 2017;8:133.
Article PubMed PubMed Central Google Scholar
Vincent TL, McClurg O, Troeberg L. The Extracellular matrix of articular cartilage controls the bioavailability of pericellular matrix-bound growth factors to drive tissue homeostasis and repair. Int J Mol Sci. 2022;23:6003.
Article CAS PubMed PubMed Central Google Scholar
Kolberg L, Raudvere U, Kuzmin I, Adler P, Vilo J, Peterson H. Profiler-interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update). Nucleic Acids Res. 2023;51:W207–12.
Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthritis Cartilage. 2007;15:1061–9.
Gulfam M, Jo SH, Jo SW, Vu TT, Park SH, Lim KT. Highly porous and injectable hydrogels derived from cartilage acellularized matrix exhibit reduction and NIR light dual-responsive drug release properties for application in antitumor therapy. NPG Asia Mater. 2022;14:8.
Goldring MB, Goldring SR. Osteoarthritis. J Cell Physiol. 2007;213:626–34.
Article CAS PubMed Google Scholar
Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Ther Adv Musculoskelet Dis. 2013;5:77–94.
Article CAS PubMed PubMed Central Google Scholar
Haseeb A, Haqqi TM. Immunopathogenesis of osteoarthritis. Clin Immunol. 2013;146:185–96.
Article CAS PubMed PubMed Central Google Scholar
Goldring MB, Marcu KB. Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther. 2009;11:224.
Article PubMed PubMed Central Google Scholar
Scotti C, Wirz D, Wolf F, Schaefer DJ, Bürgin V, Daniels AU, et al. Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds. Biomaterials. 2010;31:2252–9.
John R, Ma J, Wong I. Better clinicoradiological results of BST-CarGel treatment in cartilage repair compared with microfracture in acetabular chondral defects at 2 Years. Am J Sports Med. 2020;48:1961–6.
van der Kraan PM, van den Berg WB. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration. Osteoarthritis Cartilage. 2012;20:223–32.
Toh WS, Spector M, Lee EH, Cao T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Mol Pharm. 2011;8:994–1001.
Article CAS PubMed Google Scholar
Chang NJ, Lin YT, Lin CC, Wang HC, Hsu HC, Yeh ML. The repair of full-thickness articular cartilage defect using intra-articular administration of N-acetyl-D-glucosamine in the rabbit knee: randomized controlled trial. Biomed Eng Online. 2015;14:105.
Wang M, Wu Y, Li G, Lin Q, Zhang W, Liu H, et al. Articular cartilage repair biomaterials: strategies and applications. Mater Today Bio. 2024;24: 100948.
McInnes AD, Moser MAJ, Chen X. Preparation and use of decellularized extracellular matrix for tissue engineering. J Funct Biomater. 2022;13:240.
Article CAS PubMed PubMed Central Google Scholar
Yu X, Zhang H, Miao Y, Xiong S, Hu Y. Recent strategies of collagen-based biomaterials for cartilage repair: from structure cognition to function endowment. J Leather Sci Eng. 2022;4:11.
Sodhi H, Panitch A. Glycosaminoglycans in tissue engineering: a review. Biomolecules. 2020;11:29.
Article PubMed PubMed Central Google Scholar
Gilbert TW, Sellaro TL, Badylak SF. Decellularization of tissues and organs. Biomaterials. 2006;27:3675–83.
Posey KL, Coustry F, Hecht JT. Cartilage oligomeric matrix protein: COMPopathies and beyond. Matrix Biol. 2018;71–72:161–73.
Article PubMed PubMed Central Google Scholar
Maly K, Andres Sastre E, Farrell E, Meurer A, Zaucke F. COMP and TSP-4: functional roles in articular cartilage and relevance in osteoarthritis. Int J Mol Sci. 2021;22:2242.
Gelse K, Klinger P, Koch M, Surmann-Schmitt C, von der Mark K, Swoboda B, et al. Thrombospondin-1 prevents excessive ossification in cartilage repair tissue induced by osteogenic protein-1. Tissue Eng Part A. 2011;17:2101–12.
Sweetwyne MT, Murphy-Ullrich JE. Thrombospondin1 in tissue repair and fibrosis: TGF-beta-dependent and independent mechanisms. Matrix Biol. 2012;31:178–86.
Article CAS PubMed PubMed Central Google Scholar
Doyen V, Rubio M, Braun D, Nakajima T, Abe J, Saito H, et al. Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation. J Exp Med. 2003;198:1277–83.
Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, et al. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell. 1998;93:1159–70.
Nicolae C, Ko YP, Miosge N, Niehoff A, Studer D, Enggist L, et al. Abnormal collagen fibrils in cartilage of matrilin-1/matrilin-3-deficient mice. J Biol Chem. 2007;282:22163–75.
Muttigi MS, Han I, Park HK, Park H, Lee SH. Matrilin-3 role in cartilage development and osteoarthritis. Int J Mol Sci. 2016;17:590.
Delhon L, Mougin Z, Jonquet J, Bibimbou A, Dubail J, Bou-Chaaya C, et al. The critical role of the TB5 domain of fibrillin-1 in endochondral ossification. Hum Mol Genet. 2022;31:3777–88.
Sedes L, Wondimu E, Crockett B, Hansen J, Cantalupo A, Asano K, et al. Fibrillin-1 deficiency in the outer perichondrium causes longitudinal bone overgrowth in mice with Marfan syndrome. Hum Mol Genet. 2022;31:3281–9.
Allbritton-King JD, Kimicata M, Fisher JP. Incorporating a structural extracellular matrix gradient into a porcine urinary bladder matrix-based hydrogel dermal scaffold. J Biomed Mater Res A. 2021;109:1893–904.
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