Research ArticleCell biologyOncology Open Access | 10.1172/JCI168277

Callum Beach,1 David MacLean,1 Dominika Majorova,1 Stavros Melemenidis,2 Dhanya K. Nambiar,2 Ryan K. Kim,2 Gabriel N. Valbuena,3 Silvia Guglietta,4,5 Carsten Krieg,5,6 Mahnaz Darvish-Damavandi,7 Tatsuya Suwa,1 Alistair Easton,1 Lily V.S. Hillson,8 Ashley K. McCulloch,8 Ross K. McMahon,8 Kathryn Pennel,8 Joanne Edwards,8 Sean M. O’Cathail,8 Campbell S. Roxburgh,8 Enric Domingo,1 Eui Jung Moon,1,2 Dadi Jiang,9 Yanyan Jiang,1 Qingyang Zhang,1 Albert C. Koong,9 Trent M. Woodruff,10 Edward E. Graves,2 Tim Maughan,1 Simon J.A. Buczacki,7 Manuel Stucki,11 Quynh-Thu Le,2 Simon J. Leedham,3 Amato J. Giaccia,1,2 and Monica M. Olcina1,2,11

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Beach, C. in: JCI | PubMed | Google Scholar

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by MacLean, D. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Majorova, D. in: JCI | PubMed | Google Scholar

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Melemenidis, S. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Nambiar, D. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Kim, R. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Valbuena, G. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Guglietta, S. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Krieg, C. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Darvish-Damavandi, M. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Suwa, T. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Easton, A. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Hillson, L. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by McCulloch, A. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by McMahon, R. in: JCI | PubMed | Google Scholar

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Pennel, K. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Edwards, J. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by O’Cathail, S. in: JCI | PubMed | Google Scholar

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Roxburgh, C. in: JCI | PubMed | Google Scholar

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Domingo, E. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Moon, E. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Jiang, D. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Jiang, Y. in: JCI | PubMed | Google Scholar |

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom.

9The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

10School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.

11Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Address correspondence to: Monica M. Olcina, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ, United Kingdom. Phone: 44.0.1865.617355; Email: monica.olcina@oncology.ox.ac.uk.

Authorship note: CB, D MacLean, and D Majorova are co–first authors.

Find articles by Zhang, Q. in: JCI | PubMed | Google Scholar

1Department of Oncology, University of Oxford, Oxford, United Kingdom.

2Department of Radiation Oncology, Stanford University, Stanford, California, USA.

3Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

4Department of Regenerative Medicine and Cell Biology,

5Hollings Cancer Center, and

6Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

7Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

8School of Cancer Sciences, University o