Examining the effect of activated cytotoxic (CD8+) T-cell exosomes to the lung cancer

Wang J, Wang X. Beyond chemotherapy and targeted therapy: adoptive cellular therapy in non-small cell lung cancer. Mol Biol Rep. 2014. https://doi.org/10.1007/s11033-014-3514-x.

Article  PubMed  PubMed Central  Google Scholar 

Geltink RIK, Kyle RL, Pearce EL. Unraveling the complex interplay between T cell metabolism and function. Annu Rev Immunol. 2018. https://doi.org/10.1146/annurev-immunol-042617-053019.

Article  PubMed  Google Scholar 

Lu J, Wu J, Tian J, Wang S. Role of T cell-derived exosomes in immunoregulation. Immunol Res. 2018. https://doi.org/10.1007/s12026-018-9000-0.

Article  PubMed  Google Scholar 

Li K, Zhang Q, Zhang Y, Yang J, Zheng J. T-cell-associated cellular immunotherapy for lung cancer. Cancer Res Clin Oncol. 2015. https://doi.org/10.1007/s00432-014-1867-0.

Article  Google Scholar 

Shao Y, Pan X, Fu R. Role and function of T cell-derived exosomes and their therapeutic value. Mediators Inflamm. 2021. https://doi.org/10.1155/2021/8481013.

Article  PubMed  PubMed Central  Google Scholar 

Batista IA, Melo SA. Exosomes and the future of immunotherapy in pancreatic cancer. Int J Mol Sci. 2019. https://doi.org/10.3390/ijms20030567.

Article  PubMed  PubMed Central  Google Scholar 

Zhou Q, Wei S, Wang H, Li Y, Fan S, Cao Y, et al. T cell-derived exosomes in tumor immune modulation and immunotherapy. Front Immunol. 2023. https://doi.org/10.3389/fimmu.2023.1130033.

Article  PubMed  PubMed Central  Google Scholar 

Seo N, Shirakura Y, Tahara Y, Momose F, Harada N, Ikeda H, Akiyoshi K, Shiku H. Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells. Nat Commun. 2018. https://doi.org/10.1038/s41467-018-02865-1.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Lei F, Tan H. The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer. Front Immunol. 2023. https://doi.org/10.3389/fimmu.2023.1166128.

Article  PubMed  PubMed Central  Google Scholar 

Pierzchalski A, Mittag A, Bocsi J, Tarnok A. An innovative cascade system for simultaneous separation of multiple cell types. PLoS ONE. 2013. https://doi.org/10.1371/journal.pone.0074745.

Article  PubMed  PubMed Central  Google Scholar 

Trickett A, Kwan YL. T cell stimulation and expansion using anti-CD3/CD28 beads. J Immunol Methods. 2003. https://doi.org/10.1016/S0022-1759(03)00010-3.

Article  PubMed  Google Scholar 

Kalamasz D, Long SA, Taniguchi R, Buckner JH, Berenson RJ, Bonyhadi M. Optimization of human T-cell expansion ex vivo using magnetic beads conjugated with anti-CD3 and anti-CD28 antibodies. J Immunother. 2004. https://doi.org/10.1097/00002371-200409000-00010.

Article  PubMed  Google Scholar 

Xu H, Wang N, Cao W, Huang L, Zhou J, Sheng L. Influence of various medium environment to in vitro human T cell culture. In Vitro Cell Dev Biol Anim. 2018. https://doi.org/10.1007/s11626-018-0273-3.

Article  PubMed  Google Scholar 

Al-Shanti N, Aldahoudi Z. Human purified CD8+ T cells: ex vivo expansion model to generate a maximum yield of functional cytotoxic cells. Immunol Investig. 2007. https://doi.org/10.1080/08820130600991950.

Article  Google Scholar 

Lässer C, Eldh M, Lötvall J. Isolation and characterization of RNA-containing exosomes. J Vis Exp. 2012. https://doi.org/10.3791/3037.

Article  PubMed  PubMed Central  Google Scholar 

Oz Oyar E, Aciksari A, Azak Pazarlar B, Egilmez CB, Duruksu G, Rencber SF, et al. The therapeutical effects of damage-specific stress induced exosomes on the cisplatin nephrotoxicity in vivo. Mol Cell Probes. 2022. https://doi.org/10.1016/j.mcp.2022.101861.

Article  PubMed  Google Scholar 

Seo N, Akiyoshi K, Shiku H. Exosome-mediated regulation of tumor immunology. Cancer Sci. 2018. https://doi.org/10.1111/cas.13735.

Article  PubMed  PubMed Central  Google Scholar 

Raskov H, Orhan A, Christensen JP, Gögenur I. Cytotoxic CD8+ T cells in cancer and cancer immunotherapy. Br J Cancer. 2021. https://doi.org/10.1038/s41416-020-01048-4.

Article  PubMed  Google Scholar 

Jiang X, Xu J, Liu M, Xing H, Wang Z, Huang L, Mellor AL, et al. Adoptive CD8+ T cell therapy against cancer: challenges and opportunities. Cancer Lett. 2019. https://doi.org/10.1016/j.canlet.2019.07.017.

Article  PubMed  PubMed Central  Google Scholar 

Sun S, Hao H, Yang G, Zhang Y, Fu Y. Immunotherapy with CAR-modified T cells: toxicities and overcoming strategies. J Immunol Res. 2018. https://doi.org/10.1155/2018/2386187.

Article  PubMed  PubMed Central  Google Scholar 

Dabas P, Danda A. Revolutionizing cancer treatment: a comprehensive review of CAR-T cell therapy. Med Oncol. 2023. https://doi.org/10.1007/s12032-023-02146-y.

Article  PubMed  Google Scholar 

Xu M, Yang Q, Sun X, Wang Y. Recent advancements in the loading and modification of therapeutic exosomes. Front Bioeng Biotechnol. 2020. https://doi.org/10.3389/fbioe.2020.586130.

Article  PubMed  PubMed Central  Google Scholar 

Hazrati A, Soudi S, Malekpour K, Mahmoudi M, Rahimi A, Hashemi SM, et al. Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications. Biomark Res. 2022. https://doi.org/10.1186/s40364-022-00374-4.

Article  PubMed  PubMed Central  Google Scholar 

Wahlgren J, Karlson TL, Glader P, Telemo E, Valadi H. Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling. PLoS ONE. 2012. https://doi.org/10.1371/journal.pone.0049723.

Article  PubMed  PubMed Central  Google Scholar 

Zhang H, Wang S, Sun M, Cui Y, Xing J, Teng L, et al. Exosomes as smart drug delivery vehicles for cancer immunotherapy. Front Immunol. 2023. https://doi.org/10.3389/fimmu.2022.1093607.

Article  PubMed  PubMed Central  Google Scholar 

Li L, Jay SM, Wang Y, Wu SW, Xiao Z. IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells. Sci Rep. 2017. https://doi.org/10.1038/s41598-017-14000-z.

Article  PubMed  PubMed Central  Google Scholar 

Cai Z, Yang F, Yu L, Yu Z, Jiang L, Wang Q, et al. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol. 2012. https://doi.org/10.4049/jimmunol.1103466.

Article  PubMed  Google Scholar 

Merikallio H, Turpeenniemi-Hujanen T, Pääkkö P, Mäkitaro R, Riitta K, Salo S, et al. Snail promotes an invasive phenotype in lung carcinoma. Respir Res. 2012. https://doi.org/10.1186/1465-9921-13-104.

Article  PubMed  PubMed Central  Google Scholar 

Wang G, Ma W, Li Y, Jiang Y, Ma G, Zhang X, et al. Prognostic value of Twist, Snail and E-cadherin expression in pathological N0 non-small-cell lung cancer: a retrospective cohort study. Eur J Cardiothorac Surg. 2018. https://doi.org/10.1093/ejcts/ezy022.

Article  PubMed  PubMed Central  Google Scholar 

Wang G, Dong W, Shen H, Mu X, Li Z, Lin X, et al. A comparison of Twist and E-cadherin protein expression in primary non-small-cell lung carcinoma and corresponding metastases. Eur J Cardiothorac Surg. 2011. https://doi.org/10.1016/j.ejcts.2011.01.023.

Article  PubMed  PubMed Central  Google Scholar 

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