Redefining the Reference Interval and Cut-Off Values of the Hematological and Biochemical Parameters and Deriving a Sensitive Predictive Marker for Crisis Events in Sickle Cell Disease

Inusa BPD, Hsu LL, Kohli N, Patel A, Ominu-Evbota K, Anie KA, et al. Sickle cell disease—genetics, pathophysiology, clinical presentation and treatment. Int J Neonatal Screen. 2019;5(2):20.

Article  PubMed  PubMed Central  Google Scholar 

Patra PK, Chauhan VS, Khodiar PK, Dalla AR, Serjeant GR. Screening for the sickle cell gene in Chhattisgarh state, India: an approach to a major public health problem. J Community Genet. 2011;2(3):147–51.

Article  PubMed  PubMed Central  Google Scholar 

Patel S, Nanda R, Hussain N, Mohapatra E, Patra PK. Frequency distribution of the methylenetetrahydrofolate reductase polymorphisms in sickle cell hemoglobinopathy-A hospital based study in central India. Clin Epidemiol Glob Health. 2021;10(100669):1–7.

CAS  Google Scholar 

Thaker P, Colah RB, Patel J, Raicha B, Mistry A, Mehta V, et al. Newborn screening for sickle cell disease among tribal populations in the states of Gujarat and Madhya Pradesh in India: evaluation and outcome over 6 years. Front Med. 2022;8(731884):1–8.

Google Scholar 

Sundd P, Gladwin MT, Novelli EM. Pathophysiology of sickle cell disease. Annu Rev Pathol. 2019;24(14):263–92.

Article  Google Scholar 

Akinbami A, Dosunmu A, Adediran A, Oshinaike O, Adebola P, Arogundade O. Haematological values in homozygous sickle cell disease in steady state and haemoglobin phenotypes AA controls in Lagos, Nigeria. BMC Res Notes. 2012;1(5):396.

Article  Google Scholar 

Fome AD, Sangeda RZ, Balandya E, Mgaya J, Soka D, Tluway F, et al. Hematological and biochemical reference ranges for the population with sickle cell disease at steady state in Tanzania. Hemato. 2022;3(1):82–97.

Article  Google Scholar 

Sahli CA, Bibi A, Ouali F, Fredj SH, Dakhlaoui B, Othmani R, et al. Red cell indices: differentiation between β-thalassemia trait and iron deficiency anemia and application to sickle-cell disease and sickle-cell thalassemia. Clin Chem Lab Med. 2013;51(11):2115–24.

Article  CAS  PubMed  Google Scholar 

Khaled SAA, Ahmed HA, Elbadry MI, NasrEldin E, Hassany SM, Ahmed SA. Hematological, biochemical properties, and clinical correlates of hemoglobin S variant disorder: a new insight into sickle cell trait. J Hematol. 2022;11(3):92–108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Green R, King R. A new red cell discriminant incorporating volume dispersion for differentiating iron deficiency anemia from thalassemia minor. Blood Cells. 1989;15(3):481–91; discussion 492–495.

Ehsani MA, Shahgholi E, Rahiminejad MS, Seighali F, Rashidi A. A new index for discrimination between iron deficiency anemia and beta-thalassemia minor: results in 284 patients. Pak J Biol Sci PJBS. 2009;12(5):473–5.

Article  CAS  PubMed  Google Scholar 

Shine I, Lal S. A strategy to detect beta-thalassaemia minor. Lancet Lond Engl. 1977;1(8013):692–4.

Article  CAS  Google Scholar 

Huber A, Ottiger C, Risch L, Regenass S, Hergersberg M, Herklotz R. Thalassämie-syndrome: klinik und diagnose syndromes thalassémiques: clinique et diagnostic. Swiss Med Forum. 2004;8(4):947–52.

Google Scholar 

Sirdah M, Tarazi I, Al Najjar E, Al HR. Evaluation of the diagnostic reliability of different RBC indices and formulas in the differentiation of the beta-thalassaemia minor from iron deficiency in Palestinian population. Int J Lab Hematol. 2008;30(4):324–30.

Article  CAS  PubMed  Google Scholar 

Olawale OO, Adekanmbi AF, Sonuga AA, Sonuga OO, Akodu SO, Ogundeyi MM. Assessment of renal function status in steady-state sickle cell anaemic children using urine human neutrophil gelatinase-associated lipocalin and albumin: creatinine ratio. Med Princ Pract. 2021;30(6):557–62.

Article  PubMed  PubMed Central  Google Scholar 

Ko A, Ic I, So O, Eo DI, Ri E, E O, et al. Renal function of sickle cell subjects in Edo State-Nigeria. Arch Nephrol Urol. 2018;1(1):1–8.

Article  Google Scholar 

Antwi-Boasiako C, Kusi-Mensah YA, Hayfron-Benjamin C, Aryee R, Dankwah GB, Abla KL, et al. Serum potassium, sodium, and chloride levels in sickle cell disease patients and healthy controls: a case-control study at Korle-Bu Teaching Hospital, Accra. Biomark Insights. 2019;14(1177271919873889):1–5.

Google Scholar 

Mansoor F, Bai P, Kaur N, Sultan S, Sharma S, Dilip A, et al. Evaluation of serum electrolyte levels in patients with anemia. Cureus. 2021;13(10):e18417.

PubMed  PubMed Central  Google Scholar 

Pandey S, Sharma A, Dahia S, Shah V, Sharma V, Mishra RM, et al. Biochemical indicator of sickle cell disease: preliminary report from India. Indian J Clin Biochem. 2012;27(2):191–5.

Article  CAS  PubMed  Google Scholar 

Cu O. Enzyme activities of liver function (Biomarkers) in sickle cell anaemic patients attending Sickle Cell Anaemic Centre, Benin City, Edo State, Nigeria. Int J Blood Res Disord. 2020;7(2):1–5.

Google Scholar 

Makulo JR, Itokua KE, Lepira RK, Bundutidi GM, Aloni MN, Ngiyulu RM, et al. Magnitude of elevated iron stores and risk associated in steady state sickle cell anemia Congolese children: a cross sectional study. BMC Hematol. 2019;19(3):1–6.

Google Scholar 

Akodu SO, Diaku-Akinwumi IN, Kehinde OA, Njokanma OF. Serum iron status of under-five children with sickle cell anaemia in Lagos, Nigeria. Anemia. 2013;2013(e254765):1–7.

Article  Google Scholar 

Feugray G, Kasonga F, Grall M, Benhamou Y, Bobée-Schneider V, Buchonnet G, et al. Assessment of reticulocyte and erythrocyte parameters from automated blood counts in vaso-occlusive crisis on sickle cell disease. Front Med. 2022;9(858911):1–8.

Google Scholar 

Nader E, Romana M, Connes P. The red blood cell—inflammation vicious circle in sickle cell disease. Front Immunol. 2020;11(454):1–11.

Google Scholar 

Yildirim N, Unal S, Yalcinkaya A, Karahan F, Oztas Y. Evaluation of the relationship between intravascular hemolysis and clinical manifestations in sickle cell disease: decreased hemopexin during vaso-occlusive crises and increased inflammation in acute chest syndrome. Ann Hematol. 2022;101(1):35–41.

Article  CAS  PubMed  Google Scholar 

Torres LS, Okumura JV, Silva DGH, Mimura KKO, Belini-Júnior É, Oliveira RG, et al. Inflammation in sickle cell disease: differential and down-expressed plasma levels of annexin A1 protein. PLoS ONE. 2016;11(11):e0165833.

Article  PubMed  PubMed Central  Google Scholar 

Ahmed HA, Khaled SAA, Fahmy EM, Mohammed NA, Mahmoud HFF. Significance of the mathematically calculated red cell indices in patients with qualitative and quantitative hemoglobinopathies. Egypt J Int Med. 2022;34(1):1–9.

Article  Google Scholar 

Lakhani J, Kalaria T, Sanghavi A, Chordiya R. A study of blood indices in Sickle cell disorder. Ann Trop Med Public Health. 2020;23(23):1–11.

Google Scholar 

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