Exosomes isolated from metabolically unhealthy normal weight and overweight phenotypes deteriorate the ER/PR positive breast cancer behavior

La Camera G, Gelsomino L, Malivindi R, Barone I, Panza S, De Rose D, et al. Adipocyte-derived extracellular vesicles promote breast cancer cell malignancy through HIF-1α activity. Cancer Lett. 2021;521:155–68.

Article  PubMed  Google Scholar 

Nagrani R, Mhatre S, Rajaraman P, Soerjomataram I, Boffetta P, Gupta S, et al. Central obesity increases risk of breast cancer irrespective of menopausal and hormonal receptor status in women of south asian ethnicity. Eur J Cancer. 2016;66:153–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cotterchio M, Kreiger N, Theis B, Sloan M, Bahl S. Hormonal factors and the risk of breast cancer according to estrogen-and progesterone-receptor subgroup. Cancer Epidemiol Biomarkers Prev. 2003;12(10):1053–60.

CAS  PubMed  Google Scholar 

White AJ, Nichols HB, Bradshaw PT, Sandler DP. Overall and central adiposity and breast cancer risk in the Sister Study. Cancer. 2015;121(20):3700–8.

Article  PubMed  Google Scholar 

Tsang J, Tse GM. Molecular classification of breast cancer. Adv Anat Pathol. 2020;27(1):27–35.

Article  CAS  PubMed  Google Scholar 

Suzuki R, Saji S, Toi M. Impact of body mass index on breast cancer in accordance with the life-stage of women. Front Oncol. 2012;2:123.

Article  PubMed  PubMed Central  Google Scholar 

Klein S, Wadden T, Sugerman HJ. AGA technical review on obesity. Gastroenterology. 2002;123(3):882–932.

Article  PubMed  Google Scholar 

Wang B, Zhang M, Wang S, Wang C, Wang J, Li L, et al. Dynamic status of metabolically healthy overweight/obesity and metabolically unhealthy and normal weight and the risk of type 2 diabetes mellitus: a cohort study of a rural adult chinese population. Obes Res Clin Pract. 2018;12(1):61–71.

Article  PubMed  Google Scholar 

Park YMM, White AJ, Nichols HB, O’Brien KM, Weinberg CR, Sandler DP. The association between metabolic health, obesity phenotype and the risk of breast cancer. Int J Cancer. 2017;140(12):2657–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kabat GC, Kim MY, Lee JS, Ho GY, Going SB, Beebe-Dimmer J, et al. Metabolic obesity phenotypes and risk of breast Cancer in postmenopausal WomenMetabolic obesity phenotypes and breast Cancer. Cancer Epidemiol Biomarkers Prev. 2017;26(12):1730–5.

Article  PubMed  PubMed Central  Google Scholar 

Guo W, Gao Y, Li N, Shao F, Wang C, Wang P, et al. Exosomes: New players in cancer. Oncol Rep. 2017;38(2):665–75.

Article  PubMed  PubMed Central  Google Scholar 

Reza AMMT, Choi Y-J, Yasuda H, Kim J-H. Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells. Sci Rep. 2016;6(1):1–15.

Article  Google Scholar 

Milman N, Ginini L, Gil Z. Exosomes and their role in tumorigenesis and anticancer drug resistance. Drug Resist Updates. 2019;45:1–12.

Article  Google Scholar 

Giordano C, La Camera G, Gelsomino L, Barone I, Bonofiglio D, Andò S, et al. The biology of exosomes in breast cancer progression: dissemination, immune evasion and metastatic colonization. Cancers. 2020;12(8):2179.

Article  CAS  PubMed  PubMed Central  Google Scholar 

La Camera G, Gelsomino L, Caruso A, Panza S, Barone I, Bonofiglio D, et al. The emerging role of extracellular vesicles in endocrine resistant breast cancer. Cancers. 2021;13(5):1160.

Article  PubMed  PubMed Central  Google Scholar 

Clement E, Lazar I, Attané C, Carrié L, Dauvillier S, Ducoux-Petit M, et al. Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells. EMBO J. 2020;39(3):e102525.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lazar I, Clement E, Dauvillier S, Milhas D, Ducoux-Petit M, LeGonidec S, et al. Adipocyte exosomes promote Melanoma aggressiveness through fatty acid oxidation: a novel mechanism linking obesity and CancerAdipocyte exosomes: a new link between obesity and Cancer. Cancer Res. 2016;76(14):4051–7.

Article  CAS  PubMed  Google Scholar 

Wang J, Wu Y, Guo J, Fei X, Yu L, Ma S. Adipocyte-derived exosomes promote lung cancer metastasis by increasing MMP9 activity via transferring MMP3 to lung cancer cells. Oncotarget. 2017;8(47):81880.

Article  PubMed  PubMed Central  Google Scholar 

Lin R, Wang S, Zhao RC. Exosomes from human adipose-derived mesenchymal stem cells promote migration through wnt signaling pathway in a breast cancer cell model. Mol Cell Biochem. 2013;383:13–20.

Article  CAS  PubMed  Google Scholar 

Wang S, Su X, Xu M, Xiao X, Li X, Li H, et al. Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway. Stem Cell Res Ther. 2019;10:1–12.

Article  Google Scholar 

Ramos-Andrade I, Moraes J, Brandão-Costa RM, da Silva SV, de Souza A, da Silva C, et al. Obese adipose tissue extracellular vesicles raise breast cancer cell malignancy. Endocrine-related Cancer. 2020;27(10):571–82.

Article  CAS  PubMed  Google Scholar 

Jafari N, Llevenes P, Denis GV. Exosomes as novel biomarkers in metabolic disease and obesity-related cancers. Nat Reviews Endocrinol. 2022;18(6):327–8.

Article  Google Scholar 

Khalyfa A, Masa JF, Qiao Z, González M, Marti S, Khalyfa AA et al. Plasma exosomes in obesity hypoventilation syndrome patients drive lung cancer cell malignant properties: Effect of long-term adherent CPAP treatment. Biochimica et Biophysica Acta (BBA)-Molecular basis of Disease. 2022;1868(10):166479.

Sadegh-Nejadi S, Afrisham R, Emamgholipour S, Izadi P, Eivazi N, Tahbazlahafi B, et al. Influence of plasma circulating exosomes obtained from obese women on tumorigenesis and tamoxifen resistance in MCF‐7 cells. IUBMB Life. 2020;72(9):1930–40.

Article  CAS  PubMed  Google Scholar 

Ellis KJ, Bell SJ, Chertow GM, Chumlea WC, Knox TA, Kotler DP et al. Bioelectrical impedance methods in clinical research: a follow-up to the NIH Technology Assessment Conference. Nutrition. 1999;15(11–12):874 – 80.

Consultation W. Obesity: preventing and managing the global epidemic. Volume 894. World Health Organization technical report series; 2000. pp. 1–253.

Wildman RP, Muntner P, Reynolds K, McGinn AP, Rajpathak S, Wylie-Rosett J, et al. The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999–2004). Arch Intern Med. 2008;168(15):1617–24.

Article  PubMed  Google Scholar 

Tohidi M, Ghasemi A, Hadaegh F, Derakhshan A, Chary A, Azizi F. Age-and sex-specific reference values for fasting serum insulin levels and insulin resistance/sensitivity indices in healthy iranian adults: Tehran lipid and glucose study. Clin Biochem. 2014;47(6):432–8.

Article  CAS  PubMed  Google Scholar 

Théry C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protocols cell Biology. 2006;30(1):3. 1–3. 9.

Article  Google Scholar 

Van den Brandt PA, Spiegelman D, Yaun S-S, Adami H-O, Beeson L, Folsom AR, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152(6):514–27.

Article  PubMed  Google Scholar 

Morimoto LM, White E, Chen Z, Chlebowski RT, Hays J, Kuller L, et al. Obesity, body size, and risk of postmenopausal breast cancer: the Women’s Health Initiative (United States). Cancer Causes Control. 2002;13:741–51.

Article  PubMed  Google Scholar 

Lahmann PH, Hoffmann K, Allen N, Van Gils CH, Khaw KT, Tehard B, et al. Body size and breast cancer risk: findings from the european prospective investigation into Cancer and Nutrition (EPIC). Int J Cancer. 2004;111(5):762–71.

Article  CAS  PubMed  Google Scholar 

Neuhouser ML, Aragaki AK, Prentice RL, Manson JE, Chlebowski R, Carty CL, et al. Overweight, obesity, and postmenopausal invasive breast cancer risk: a secondary analysis of the women’s health initiative randomized clinical trials. JAMA Oncol. 2015;1(5):611–21.

Article  PubMed  PubMed Central  Google Scholar 

Wu Q, Li B, Li Z, Li J, Sun S, Sun S. Cancer-associated adipocytes: Key players in breast cancer progression. J Hematol Oncol. 2019;12:1–15.

Article  Google Scholar 

Yang H, Liang J, Zhou J, Mi J, Ma K, Fan Y, et al. Knockdown of RHOC by shRNA suppresses invasion and migration of cholangiocellular carcinoma cells via inhibition of MMP2, MMP3, MMP9 and epithelial-mesenchymal transition. Mol Med Rep. 2016;13(6):5255–61.

Article  CAS  PubMed  Google Scholar 

Radisky ES, Radisky DC. Matrix metalloproteinases as breast cancer drivers and therapeutic targets. Front Biosci (Landmark Ed). 2015;20(7):1144–63.

Article  CAS  PubMed  Google Scholar 

Allott EH, Lysaght J, Cathcart MC, Donohoe CL, Cummins R, McGarrigle SA, et al. MMP9 expression in oesophageal adenocarcinoma is upregulated with visceral obesity and is associated with poor tumour differentiation. Mol Carcinog. 2013;52(2):144–54.

Article  PubMed  Google Scholar 

Reggiani F, Labanca V, Mancuso P, Rabascio C, Talarico G, Orecchioni S, et al. Adipose progenitor cell secretion of GM-CSF and MMP9 promotes a stromal and immunological microenvironment that supports breast cancer progression. Cancer Res. 2017;77(18):5169–82.

Article  CAS  PubMed  Google Scholar 

Boumiza S, Chahed K, Tabka Z, Jacob M-P, Norel X, Ozen G. MMPs and TIMPs levels are correlated with anthropometric parameters, blood pressure, and endothelial function in obesity. Sci Rep. 2021;11(1):20052.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui H, Schroering A, Ding H-F. p53 mediates DNA damaging drug-induced apoptosis throug

Comments (0)

No login
gif