Metabolic adaptations in pressure overload hypertrophic heart

Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS (2023) Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res 118:3272–3287. https://doi.org/10.1093/cvr/cvac013

Article  CAS  PubMed  Google Scholar 

Gibb AA, Hill BG (2018) Metabolic coordination of physiological and pathological cardiac remodeling. Circ Res 123:107–128. https://doi.org/10.1161/CIRCRESAHA.118.312017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Savarese G, Lund LH (2017) Global public health burden of heart failure. Card Fail Rev 3:7–11. https://doi.org/10.15420/cfr.2016:25:2

Redfield MM, Borlaug BA (2023) Heart failure with preserved ejection fraction: a review. JAMA 329:827–838. https://doi.org/10.1001/jama.2023.2020

Article  PubMed  Google Scholar 

Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED (2021) Cardiac energy metabolism in heart failure. Circ Res 128:1487–1513. https://doi.org/10.1161/CIRCRESAHA.121.318241

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ritterhoff J, Tian R (2023) Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges. Nat Rev Cardiol. https://doi.org/10.1038/s41569-023-00887-x

Article  PubMed  Google Scholar 

Ritterhoff J, Tian R (2017) Metabolism in cardiomyopathy: every substrate matters. Cardiovasc Res 113:411–421. https://doi.org/10.1093/cvr/cvx017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho KL, Karwi QG, Wagg C, Zhang L, Vo K, Altamimi T, Uddin GM, Ussher JR, Lopaschuk GD (2021) Ketones can become the major fuel source for the heart but do not increase cardiac efficiency. Cardiovasc Res 117:1178–1187. https://doi.org/10.1093/cvr/cvaa143

Article  CAS  PubMed  Google Scholar 

Kolwicz SC, Purohit S Jr, Tian R (2013) Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res 113:603–616. https://doi.org/10.1161/CIRCRESAHA.113.302095

Article  CAS  PubMed  Google Scholar 

Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Le Z, Yanxiang GJ, White E, Rabinowitz JD (2017) Glucose feeds the TCA cycle via circulating lactate. Nature 551:115–118. https://doi.org/10.1038/nature24057

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, Rabinowitz JD, Frankel DS, Arany Z (2020) Comprehensive quantification of fuel use by the failing and nonfailing human heart. Science 370:364–368. https://doi.org/10.1126/science.abc8861

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taegtmeyer H, Wilson CR, Razeghi P, Sharma S (2005) Metabolic energetics and genetics in the heart. Ann N Y Acad Sci 1047:208–218. https://doi.org/10.1196/annals.1341.019

Article  CAS  PubMed  Google Scholar 

De Jong KA, Lopaschuk GD (2017) Complex energy metabolic changes in heart failure with preserved ejection fraction and heart failure with reduced ejection fraction. Can J Cardiol 33:860–871. https://doi.org/10.1016/j.cjca.2017.03.009

Article  PubMed  Google Scholar 

Chen Z, Jin ZX, Cai J, Li R, Deng KQ, Ji YX, Lei F, Li HP, Lu Z, Li H (2022) Energy substrate metabolism and oxidative stress in metabolic cardiomyopathy. J Mol Med 100:1721–1739. https://doi.org/10.1007/s00109-022-02269-1

Article  CAS  PubMed  Google Scholar 

Karwi QG, Uddin GM, Ho KL, Lopaschuk GD (2018) Loss of metabolic flexibility in the failing heart. Front Cardiovasc Med 5:68. https://doi.org/10.3389/fcvm.2018.00068

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dugani CB, Klip A (2005) Glucose transporter 4: cycling, compartments and controversies. EMBO Rep 6:1137–1142. https://doi.org/10.1038/sj.embor.7400584

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kutsche HS, Schreckenberg R, Weber M, Hirschhauser C, Rohrbach S, Li L, Niemann B, Schulz R, Schluter KD (2020) Alterations in Glucose metabolism during the transition to heart failure: the contribution of UCP-2. Cells 9. https://doi.org/10.3390/cells9030552

Hua Y, Zhang Y, Ren J (2012) IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a. J Cell Mol Med 16:83–95. https://doi.org/10.1111/j.1582-4934.2011.01307.x

Article  CAS  PubMed  Google Scholar 

Paternostro G, Clarke K, Heath J, Seymour AM, Radda GK (1995) Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart. Cardiovasc Res 30:205–211

Article  CAS  PubMed  Google Scholar 

Razeghi P, Young ME, Alcorn JL, Moravec CS, Frazier OH, Taegtmeyer H (2001) Metabolic gene expression in fetal and failing human heart. Circulation 104:2923–2931. https://doi.org/10.1161/hc4901.100526

Article  CAS  PubMed  Google Scholar 

Paternostro G, Pagano D, Gnecchi-Ruscone T, Bonser RS, Camici PG (1999) Insulin resistance in patients with cardiac hypertrophy. Cardiovasc Res 42:246–253. https://doi.org/10.1016/s0008-6363(98)00233-8

Article  CAS  PubMed  Google Scholar 

van Gerwen J, Shun-Shion AS, Fazakerley DJ (2023) Insulin signalling and GLUT4 trafficking in insulin resistance. Biochem Soc Trans 51:1057–1069. https://doi.org/10.1042/BST20221066

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Jaswal JS, Ussher JR, Sankaralingam S, Wagg C, Zaugg M, Lopaschuk GD (2013) Cardiac insulin-resistance and decreased mitochondrial energy production precede the development of systolic heart failure after pressure-overload hypertrophy. Circ Heart Fail 6:1039–1048. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000228

Article  CAS  PubMed  Google Scholar 

Riehle C, Abel ED (2016) Insulin signaling and heart failure. Circ Res 118:1151–1169. https://doi.org/10.1161/CIRCRESAHA.116.306206

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abel ED, Kaulbach HC, Tian R, Hopkins JC, Duffy J, Doetschman T, Minnemann T, Boers ME, Hadro E, Oberste-Berghaus C, Quist W, Lowell BB, Ingwall JS, Kahn BB (1999) Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J Clin Investig 104:1703–1714. https://doi.org/10.1172/JCI7605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wende AR, Kim J, Holland WL, Wayment BE, O’Neill BT, Tuinei J, Brahma MK, Pepin ME, McCrory MA, Luptak I, Halade GV, Litwin SE, Abel ED (2017) Glucose transporter 4-deficient hearts develop maladaptive hypertrophy in response to physiological or pathological stresses. Am J Physiol Heart Circ Physiol 313:H1098–H1108. https://doi.org/10.1152/ajpheart.00101.2017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belke DD, Larsen TS, Gibbs EM, Severson DL (2001) Glucose metabolism in perfused mouse hearts overexpressing human GLUT-4 glucose transporter. Am J Physiol Endocrinol Metab 280:E420-427. https://doi.org/10.1152/ajpendo.2001.280.3.E420

Article  CAS  PubMed  Google Scholar 

Hansen PA, Gulve EA, Marshall BA, Gao J, Pessin JE, Holloszy JO, Mueckler M (1995) Skeletal muscle glucose transport and metabolism are enhanced in transgenic mice overexpressing the Glut4 glucose transporter. J Biol Chem 270:1679–1684. https://doi.org/10.1074/jbc.270.5.1679

Article  CAS  PubMed  Google Scholar 

Li J, Hu X, Selvakumar P, 3rd Russell RR, Cushman SW, Holman GD, Young LH (2004) Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am J Physiol Endocrinol Metab 287:E834-841. https://doi.org/10.1152/ajpendo.00234.2004

Article  CAS  PubMed  Google Scholar 

3rd Russel RR, Bergeron R, Shulman GI, Young LH (1999) Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. Am J Physiol 277:H643-649. https://doi.org/10.1152/ajpheart.1999.277.2.H643

Article  Google Scholar 

Tian R, Musi N, D’Agostino J, Hirshman MF, Goodyear LJ (2001) Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 104:1664–1669. https://doi.org/10.1161/hc4001.097183

Article  CAS  PubMed  Google Scholar 

Kim M, Tian R (2011) Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol 51:548–553. https://doi.org/10.1016/j.yjmcc.2010.12.004

Article  CAS  PubMed  Google Scholar 

Lund S, Holman GD, Schmitz O, Pedersen O (1995) Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc Natl Acad Sci USA 92:5817–5821. https://doi.org/10.1073/pnas.92.13.5817

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsakiridis T, Vranic M, Klip A (1995) Phospha

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