The sympathetic nervous system in heart failure revisited

Braunwald E (1997) Shattuck lecture–cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J Med 337(19):1360–1369

Article  CAS  PubMed  Google Scholar 

Giannoni A, Mirizzi G, Aimo A, Emdin M, Passino C (2015) Peripheral reflex feedbacks in chronic heart failure: is it time for a direct treatment? World J Cardiol 7(12):824–828

Article  PubMed  PubMed Central  Google Scholar 

Packer M (1995) Evolution of the neurohormonal hypothesis to explain the progression of chronic heart failure. Eur Heart J 16 Suppl F:4–6

Grassi G, Seravalle G, Quarti-Trevano F, Dell’Oro R, Bolla G, Mancia G (2003) Effects of hypertension and obesity on the sympathetic activation of heart failure patients. Hypertension 42(5):873–877

Article  CAS  PubMed  Google Scholar 

Badrov MB, Mak S, Floras JS (2021) Cardiovascular autonomic disturbances in heart failure with preserved ejection fraction. Can J Cardiol 37(4):609–620

Article  PubMed  Google Scholar 

De Angelis E, Pecoraro M, Rusciano MR, Ciccarelli M, Popolo A (2019) Cross-talk between neurohormonal pathways and the immune system in heart failure: a review of the literature. Int J Mol Sci 20(7)

Floras JS (2016) Sympathetic nervous system in patients with sleep related breathing disorders. Curr Hypertens Rev 12(1):18–26

Article  PubMed  Google Scholar 

Bohuslavova R, Cerychova R, Papousek F, Olejnickova V, Bartos M, Gorlach A, Kolar F, Sedmera D, Semenza GL, Pavlinkova G (2019) HIF-1alpha is required for development of the sympathetic nervous system. Proc Natl Acad Sci U S A 116(27):13414–13423

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hogg K, McMurray J (2005) Neurohumoral pathways in heart failure with preserved systolic function. Prog Cardiovasc Dis 47(6):357–366

Article  CAS  PubMed  Google Scholar 

Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J (2009) The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol 54(19):1747–1762

Article  CAS  PubMed  Google Scholar 

Hartupee J, Mann DL (2017) Neurohormonal activation in heart failure with reduced ejection fraction. Nat Rev Cardiol 14(1):30–38

Article  CAS  PubMed  Google Scholar 

Floras JS, Ponikowski P (2015) The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction. Eur Heart J 36(30):1974–1982b

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadaya J, Ardell JL (2020) Autonomic modulation for cardiovascular disease. Front Physiol 11:617459

Article  PubMed  PubMed Central  Google Scholar 

Ardell JL, Foreman RD, Armour JA, Shivkumar K (2019) Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during ischemia preventing ventricular fibrillation. JCI Insight 4(23)

Hicks MN, Mary DA, Walters GE (1987) Atrial receptor discharge in dogs with chronically induced difference in blood volume. J Physiol 393:491–497

Article  CAS  PubMed  PubMed Central  Google Scholar 

Triposkiadis F, Butler J, Abboud FM, Armstrong PW, Adamopoulos S, Atherton JJ, Backs J, Bauersachs J, Burkhoff D, Bonow RO et al (2019) The continuous heart failure spectrum: moving beyond an ejection fraction classification. Eur Heart J 40(26):2155–2163

Article  PubMed  PubMed Central  Google Scholar 

Triposkiadis F, Xanthopoulos A, Butler J (2020) From PARADIGM to PARAGON further evidence supporting continuous heart failure spectrum. Eur J Heart Fail 22(9):1536–1539

Article  PubMed  Google Scholar 

Floras JS (2021) The 2021 Carl Ludwig lecture. Unsympathetic autonomic regulation in heart failure: patient-inspired insights. Am J Physiol Regul Integr Comp Physiol 321(3):R338-R351

Larabee CM, Neely OC, Domingos AI (2020) Obesity: a neuroimmunometabolic perspective. Nat Rev Endocrinol 16(1):30–43

Article  PubMed  Google Scholar 

Smith MM, Minson CT (2012) Obesity and adipokines: effects on sympathetic overactivity. J Physiol 590(8):1787–1801

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lambert EA, Esler MD, Schlaich MP, Dixon J, Eikelis N, Lambert GW (2019) Obesity-Associated organ damage and sympathetic nervous activity. Hypertension 73(6):1150–1159

Article  CAS  PubMed  Google Scholar 

Grassi G, Biffi A, Seravalle G, Trevano FQ, Dell’Oro R, Corrao G, Mancia G (2019) Sympathetic neural overdrive in the obese and overweight state. Hypertension 74(2):349–358

Article  CAS  PubMed  Google Scholar 

Menendez A, Wanczyk H, Walker J, Zhou B, Santos M, Finck C (2022) Obesity and adipose tissue dysfunction: from pediatrics to adults. Genes (Basel) 13(10)

Castoldi A, Naffah de Souza C, Camara NO, Moraes-Vieira PM (2015) The macrophage switch in obesity development. Front Immunol 6:637

PubMed  Google Scholar 

Pirzgalska RM, Domingos AI (2018) Macrophages in obesity. Cell Immunol 330:183–187

Article  CAS  PubMed  Google Scholar 

Russo B, Menduni M, Borboni P, Picconi F, Frontoni S (2021) Autonomic nervous system in obesity and insulin-resistance-the complex interplay between leptin and central nervous system. Int J Mol Sci 22(10)

DeLalio LJ, Sved AF, Stocker SD (2020) Sympathetic nervous system contributions to hypertension: updates and therapeutic relevance. Can J Cardiol 36(5):712–720

Article  PubMed  Google Scholar 

Fisher JP, Paton JF (2012) The sympathetic nervous system and blood pressure in humans: implications for hypertension. J Hum Hypertens 26(8):463–475

Article  CAS  PubMed  Google Scholar 

Grassi G, Mark A, Esler M (2015) The sympathetic nervous system alterations in human hypertension. Circ Res 116(6):976–990

Article  CAS  PubMed  PubMed Central  Google Scholar 

Triposkiadis F, Xanthopoulos A, Butler J (2019) Cardiovascular aging and heart failure: JACC review topic of the week. J Am Coll Cardiol 74(6):804–813

Article  PubMed  Google Scholar 

Webb AJS, Werring DJ (2022) New Insights Into Cerebrovascular Pathophysiology and Hypertension. Stroke 53(4):1054–1064

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holwerda SW, Luehrs RE, DuBose L, Collins MT, Wooldridge NA, Stroud AK, Fadel PJ, Abboud FM, Pierce GL (2019) Elevated muscle sympathetic nerve activity contributes to central artery stiffness in young and middle-age/older adults. Hypertension 73(5):1025–1035

Article  CAS  PubMed  Google Scholar 

Nardone M, Floras JS, Millar PJ (2020) Sympathetic neural modulation of arterial stiffness in humans. Am J Physiol Heart Circ Physiol 319(6):H1338–H1346

Article  CAS  PubMed  Google Scholar 

Lau ES, Panah LG, Zern EK, Liu EE, Farrell R, Schoenike MW, Namasivayam M, Churchill TW, Curreri L, Malhotra R et al (2022) Arterial stiffness and vascular load in HFpEF: differences among women and men. J Card Fail 28(2):202–211

Article  PubMed  Google Scholar 

Grassi G, Seravalle G, Quarti-Trevano F, Dell’Oro R, Arenare F, Spaziani D, Mancia G (2009) Sympathetic and baroreflex cardiovascular control in hypertension-related left ventricular dysfunction. Hypertension 53(2):205–209

Article  CAS  PubMed  Google Scholar 

Verloop WL, Beeftink MM, Santema BT, Bots ML, Blankestijn PJ, Cramer MJ, Doevendans PA, Voskuil M (2015) A systematic review concerning the relation between the sympathetic nervous system and heart failure with preserved left ventricular ejection fraction. PLoS ONE 10(2):e0117332

Article  PubMed  PubMed Central  Google Scholar 

Whelton PK, Carey RM, Mancia G, Kreutz R, Bundy JD, Williams B (2022) Harmonization of the American College of Cardiology/American Heart Association and European Society of Cardiology/European Society of Hypertension Blood Pressure/Hypertension Guidelines: comparisons, reflections, and recommendations. Circulation 146(11):868–877

Article  PubMed  Google Scholar 

Hirooka Y (2020) Sympathetic activation in hypertension: importance of the central nervous system. Am J Hypertens 33(10):914–926

Article  CAS  PubMed  Google Scholar 

Karakas M, Koenig W (2013) Sympathetic nervous system: a crucial player modulating residual cardiovascular risk. Circ Res 112(1):13–16

Article  CAS  PubMed  Google Scholar 

Moreira HG, Lage RL, Martinez DG, Ferreira-Santos L, Rondon M, Negrao CE, Nicolau JC (2017) Sympathetic nervous activity in patients with acute coronary syndrome: a comparative study of inflammatory biomarkers. Clin Sci (Lond) 131(9):883–895

Article  CAS  PubMed  Google Scholar 

Karlsberg RP, Penkoske PA, Cryer PE, Corr PB, Roberts R (1979) Rapid activation of the sympathetic nervous system following coronary artery occlusion: relationship to infarct size, site, and haemodynamic impact. Cardiovasc Res 13(9):523–531

Article  CAS  PubMed  Google Scholar 

Bhushan S, Kondo K, Predmore BL, Zlatopolsky M, King AL, Pearce C, Huang H, Tao YX, Condit ME, Lefer DJ (2012) Selective beta2-adrenoreceptor stimulation attenuates myocardial cell death and preserves cardiac function after ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol 32(8):1865–1874

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