Tadount F, Doyon-Plourde P, Quach C. Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females?–A systematic review. Vaccine. 2019;38(3):444–59.

Article  PubMed  Google Scholar 

Cook IF. Sex differences in injection site reactions with human vaccines. Hum Vaccines. 2009;5(7):441–9.

Article  CAS  Google Scholar 

Harris T, Nair J, Fediurek J, Deeks SL. Assessment of sex-specific differences in adverse events following immunization reporting in Ontario, 2012–15. Vaccine. 2017;35(19):2600–4.

Article  PubMed  Google Scholar 

Menni C, Klaser K, May A, Polidori L, Capdevila J, Louca P, et al. Vaccine side-effects and SARS-CoV-2 infection after vaccination in users of the COVID Symptom Study app in the UK: a prospective observational study. Lancet Infect Dis. 2021;21(7):939–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Green MS, Peer V, Magid A, Hagani N, Anis E, Nitzan D. Gender differences in adverse events following the Pfizer-BioNTech COVID-19 vaccine. Nato Adv Sci Inst Se. 2022;10(2):233.

CAS  Google Scholar 

Hoffmann MA, Wieler HJ, Enders P, Buchholz H-G, Plachter B. Age- and sex-graded data evaluation of vaccination reactions after initial injection of the BNT162b2 mRNA vaccine in a local Vaccination Center in Germany. Nato Adv Sci Inst Se. 2021;9(8):911.

CAS  Google Scholar 

Shapiro JR, Roberts CW, Arcovio K, Reade L, Klein SL, Dhakal S. Effects of Biological sex and pregnancy on SARS-CoV-2 pathogenesis and vaccine outcomes. In: Klein SL, Roberts CW, editors. Sex and gender differences in infection and treatments for infectious Diseases. Current topics in Microbiology and Immunology. Second ed: Springer Nature; 2023.

Google Scholar 

Brabete AC, Greaves L, Maximos M, Huber E, Li A, Lê M-L. A sex-and gender-based analysis of adverse drug reactions: a scoping review of Pharmacovigilance Databases. Pharm. 2022;15(3):298.

Google Scholar 

Klein SL, Morgan R. The impact of sex and gender on immunotherapy outcomes. Biol Sex Differ. 2020;11(1):1–10.

Article  Google Scholar 

Robb H, Fausone CA, Rudy DR, McArthur S. Side effects from influenza vaccination: differences between returned and random surveys. Mil Med. 1996;161(1):29–32.

Article  CAS  PubMed  Google Scholar 

Alabas OA, Tashani OA, Tabasam G, Johnson MI. Gender role affects experimental pain responses: a systematic review with meta-analysis: gender role affects experimental pain responses. Eur J Pain. 2012;16(9):1211–23.

Article  CAS  PubMed  Google Scholar 

Robinson ME, Riley JL, Myers CD, Papas RK, Wise EA, Waxenberg LB, et al. Gender role expectations of pain: relationship to sex differences in pain. J Pain. 2001;2(5):251–7.

Article  CAS  PubMed  Google Scholar 

Bartley EJ, Fillingim RB. Sex differences in pain: a brief review of clinical and experimental findings. Brit J Anaesth. 2013;111(1):52–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cook I, Williamson M, Pond D. Definition of needle length required for intramuscular deltoid injection in elderly adults: an ultrasonographic study. Vaccine. 2006;24(7):937–40.

Article  CAS  PubMed  Google Scholar 

Cook IF. Evidence based route of administration of vaccines. Hum Vaccines. 2008;4(1):67–73.

Article  CAS  Google Scholar 

Poland GA, Borrud A, Jacobson RM, McDermott K, Wollan PC, Brakke D, et al. Determination of deltoid fat pad thickness: implications for needle length in adult immunization. JAMA. 1997;277(21):1709–11.

Article  CAS  PubMed  Google Scholar 

Hervé C, Laupèze B, Giudice GD, Didierlaurent AM, Silva FTD. The how’s and what’s of vaccine reactogenicity. Npj Vaccines. 2019;4(1):39.

Article  PubMed  PubMed Central  Google Scholar 

Furman D, Hejblum BP, Simon N, Jojic V, Dekker CL, Thiébaut R, et al. Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc Natl Acad Sci U S A. 2014;111(2):869–74.

Article  CAS  PubMed  Google Scholar 

Straub RH. The complex role of estrogens in inflammation. Endocr Rev. 2007;28(5):521–74.

Article  CAS  PubMed  Google Scholar 

Klein SL, Hodgson A, Robinson DP. Mechanisms of sex disparities in influenza pathogenesis. J Leukoc Biol. 2012;92(1):67–73.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engelmann F, Rivera A, Park B, Messerle-Forbes M, Jensen JT, Messaoudi I. Impact of Estrogen Therapy on Lymphocyte Homeostasis and the response to Seasonal Influenza Vaccine in Post-Menopausal Women. PLoS ONE. 2016;11(2):e0149045.

Article  PubMed  PubMed Central  Google Scholar 

Trigunaite A, Dimo J, Jørgensen TN. Suppressive effects of androgens on the immune system. Cell Immunol. 2015;294(2):87–94.

Article  CAS  PubMed  Google Scholar 

Gubbels Bupp MR, Jorgensen TN. Androgen-induced immunosuppression. Front Immunol. 2018;9:794.

Article  PubMed  PubMed Central  Google Scholar 

Bödeker B, Remschmidt C, Schmich P, Wichmann O. Why are older adults and individuals with underlying chronic diseases in Germany not vaccinated against flu? A population-based study. BMC Public Health. 2015;15(1):618.

Article  PubMed  PubMed Central  Google Scholar 

Freimuth VS, Jamison A, Hancock G, Musa D, Hilyard K, Quinn SC. The role of risk perception in flu vaccine behavior among african-american and white adults in the united states. Risk Anal. 2017;37(11):2150–63.

Article  PubMed  PubMed Central  Google Scholar 

Salmon DA, Dudley MZ, Glanz JM, Omer SB. Vaccine hesitancy causes, Consequences, and a call to action. Am J Prev Med. 2015;49(6):391–S8.

Article  Google Scholar 

Burny W, Marchant A, Hervé C, Callegaro A, Caubet M, Fissette L, et al. Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans. Vaccine. 2019;37(14):2004–15.

Article  CAS  PubMed  Google Scholar 

Asai K, Hiki N, Mimura Y, Ogawa T, Unou K, Kaminishi M. Gender differences in cytokine secretion by human peripheral blood mononuclear cells: role of estrogen in modulating LPS-induced cytokine secretion in an ex vivo septic model. Shock (Augusta Ga). 2001;16(5):340–3.

Article  CAS  PubMed  Google Scholar 

Shapiro JR, Li H, Morgan R, Chen Y, Kuo H, Ning X, et al. Sex-specific effects of aging on humoral immune responses to repeated influenza vaccination in older adults. Npj Vaccines. 2021;6(1):147.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Klein SL, Pekosz A. Sex-based Biology and the Rational Design of Influenza Vaccination Strategies. J Infect Dis. 2014;209(suppl 3):114–S9.

Article  Google Scholar 

Klein SL, Marriott I, Fish EN. Sex-based differences in immune function and responses to vaccination. T Roy Soc Trop Med H. 2015;109(1):9–15.

Article  CAS  Google Scholar 

Greaves L, Ritz SA. Sex, gender and health: mapping the landscape of research and policy. Int J Environ Res Pu. 2022;19(5):2563.

Article  Google Scholar 

Morgan R, George A, Ssali S, Hawkins K, Molyneux S, Theobald S. How to do (or not to do)… gender analysis in health systems research. Health Policy Plann. 2016;31(8):1069–78.

Article  Google Scholar 

Bem SL. The measurement of psychological androgyny. J Consult Clin Psych. 1974;42(2):155–62.

Article  CAS  Google Scholar 

Carver LF, Vafaei A, Guerra R, Freire A, Phillips SP. Gender differences: examination of the 12-item bem sex role inventory (BSRI-12) in an older brazilian population. PLoS ONE. 2013;8(10):e76356.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vafaei A, Alvarado B, Tomás C, Muro C, Martinez B, Zunzunegui MV. The validity of the 12-item Bem Sex Role Inventory in older spanish population: an examination of the androgyny model. Arch Gerontol Geriat. 2014;59(2):257–63.

Article  Google Scholar 

Ahmed T, Vafaei A, Belanger E, Phillips SP, Zunzunegui M-V. Bem Sex Role Inventory Validation in the International mobility in Aging Study. Can J Aging La Revue Can Du Vieillissement. 2016;35(3):348–60.

Article  Google Scholar 

Ahmed T, Vafaei A, Auais M, Guralnik J, Zunzunegui MV. Gender roles and physical function in older Adults: cross-sectional analysis of the International mobility in Aging Study (IMIAS). PLoS ONE. 2016;11(6):e0156828.

Article  PubMed  PubMed Central  Google Scholar 

Vafaei A, Ahmed T, Freire AdNF, Zunzunegui MV, Guerra RO. Depression, sex and gender roles in older adult populations: the International mobility in Aging Study (IMIAS). PLoS ONE. 2016;11(1):e0146867.

Article  PubMed  PubMed Central  Google Scholar 

Hart CG, Saperstein A, Magliozzi D, Westbrook L. Gender and health: beyond binary categorical measurement. J Health Soc Behav. 2019;60(1):101–18.

Article