AbdeL-Aziz AF, EL-Saeed AF, EL-Dahshan K, AL-Sayed Ebead B. Association of angiotensin-I-converting enzyme (ACE) insertion/deletion gene polymorphism with end stage renal disease in Egyptian patients. Br J Med Med Res. 2014;4(8):1763–71.

Google Scholar 

Ahluwalia TS, Ahuja M, Rai TS, Kohli HS, Sud K, Bhansali A, Khullar M. Endothelial nitric oxide synthase gene haplotypes and diabetic nephropathy among Asian Indians. Mol Cell Biochem. 2008;314:9–17.

Article  CAS  PubMed  Google Scholar 

Ali S, Mehr MT, Bilal M, Zubair M, Khan AS, Mehmood N. Angiotensin 1 converting enzyme encoding gene polymorphism in renal patients. Pakistan J Med Health Sci. 2022;16(08):890–890.

Article  Google Scholar 

Al-Janabi LM, Algenabi AHA, Mohammed AJ. Endothelial nitric oxide synthase (eNOS) 4b/a gene polymorphism and the risk of diabetic nephropathy in type 2 diabetes. Tai-Qar Med J. 2016;11(1):65–75.

Google Scholar 

Anbazhagan K, Sampathkumar K, Ramakrishnan M, Gomathi P, Gomathi S, Selvam GS. Analysis of polymorphism in renin angiotensin system and other related genes in south Indian chronic kidney disease patients. Clin Chim Acta. 2009;406:108–12.

Article  CAS  PubMed  Google Scholar 

Antoniades C, Shirodaria C, Warrick N, Cai S, de Bono J, Lee J, Leeson P, Neubauer S, Ratnatunga C, Pillai R, Refsum H, Channon KM. 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. Circulation. 2006;114(11):1193–201. https://doi.org/10.1161/CIRCULATIONAHA.106.612325.

Article  CAS  PubMed  Google Scholar 

Arfa I, Abid A, Nouria S, Elloumii Zghal H, Malouche D, Mannai L, Zorgati MM, Ben AN, Zouari B, Ben Ammar S, Ben Rayana MC, Hmida S, Blousa-Chabchoub S, Abdelhak S. Lack of association between the angiotensis converting enzyme gene (I/D) polymorphism and diabetic nephrology in Tunisian type 2 Diabetic patients. J Renin Angio Aldo. 2008;S-9:32–6.

Google Scholar 

Aucella F, Margaglione M, Grandone E, Vigilante M, Gatta G, Forcella M, Ktena M, Min AD, Salatino G, Procaccini DA, Stallone C, Gesualdo L. The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study. Nephrol Dial Transplant. 2005;20:382–6.

Article  CAS  PubMed  Google Scholar 

Bellini MH, Figueira MN, Piccoli MF, Marumo JT, Cendoroglo MS, Neto MC, Dalboni MA, Batista MC, Goes MA, Schor N. Association of endothelial nitric oxide synthase gene intron 4 polymorphism with end-stage renal disease. Nephrology. 2007;12:289–93.

Article  CAS  PubMed  Google Scholar 

Bhagat M, Raina JK, Sharma M, Sharma R, Panjaliya RK, Bali SK, Tripathi NK. Association analysis of ACE I/D genotype with gynoid chronic kidney disease patients of Jammu region (J&K). Int J Recent Sci Res. 2017;8(12):22115–7.

Google Scholar 

Buraczynska M, Ksiazek P, Zaluska W, Nowicka T, Ksiazek A. Endothelial nitric oxide synthase gene intron 4 polymorphism in patients with end-stage renal disease. Nephrol Dial Transplant. 2004;19:2302–6.

Article  CAS  PubMed  Google Scholar 

Chen H, Wei F, Wang L, Wang Z, Meng J, Jia L, Sun G, Zhang R, Li B, Yu H, Pang H, Bi X, Dong H, Jiang A, Wang L. MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis. Int J Clin Exp Med. 2015;8(3):3662–70.

PubMed  PubMed Central  Google Scholar 

Choudhry N, Nagra SA, Shafi T, Mujtaba G, Abiodullah M, Rashid N. Lack of association of insertion/deletion polymorphism in angiotensin converting enzyme gene with nephropathy in type 2 diabetic patients in Punjabi population of Pakistan. Afr J Biotech. 2012;11(6):1484–9.

CAS  Google Scholar 

Cimponeriu DG, Vladica M, Apostol PP, Panaite C, Craciun AM, Ungureanu D, Moldovan C, Serafinceanu C, Gavrila L, Cheta DM. The MTHFR C677T and eNOS ID polymorphisms increase the risk for ESRD in Romanian diabetic and nondiabetic patients. Diabetes. 2007;1(56):A92.

Google Scholar 

Deepashree GA, Ramprasad E, Jayakumar M, Paul SF, Gnanasambandan R. ACE ID gene polymorphism contributes to chronic kidney disease progression but not NOS3 gene among type 2 diabetes with nephropathy patients. Endocr Metab Sci. 2021;4:100100.

Article  Google Scholar 

Dong Q, Tang G, He M, Cai Y, Cai Y, Xing H, Sun L, Li J, Zhang Y, Fan F, Wang B, Sun N, Liu L, Xu X, Hou F, Shen H, Xu X, Huo Y. Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males. BMC Med Genet. 2012;13:74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elhawary NA, Bogari N, Rashad M, Tayeb MT. Null genetic risk of ACE gene polymorphisms with nephropathy in type 1 diabetes among Egyptian population. Egyptian J Med Human Genet. 2011;12:187–92.

Article  CAS  Google Scholar 

Elshamaa MF, Sabry SM, Bazaraa HF, Koura HF, Elghoroury EM, Kantoush NA, Thabet EH, Abd-El Haleem DA. Genetic polymorphism of ACE and the angiotensin II type1 receptor genes in children with chronic kidney disease. J Inflamm. 2011;8:20.

Article  CAS  Google Scholar 

Elumalai R, Periasamy S, Ramanathan G, Lakkakula BNKS. Role of endothelial nitric oxide synthase VNTR (intron 4 a/b) polymorphism on the progression of renal disease in autosomal dominant polycystic kidney disease. J Renal Inj Prev. 2014;3(3):69–73.

PubMed  PubMed Central  Google Scholar 

Fawwaz S, Balbaa M, Fakhoury H, Borjac J, Fakhoury R. Association between Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism and End-stage Renal Disease in Lebanese Patients with Diabetic Nephropathy. Saudi J Kidney Dis Transpl. 2017;28(2):325–9.

Article  PubMed  Google Scholar 

Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(7):829–837d. https://doi.org/10.1093/eurheartj/ehr304.

Article  CAS  PubMed  Google Scholar 

Freitas SR, Cabello PH, Moura-Neto RS, Dolinsky LC, Boia MN. Combined analysis of genetic and environmental factors on essential hypertension in a brazilian rural population in the Amazon region. Arq Bras Cardiol. 2007;88(4):447–51.

Article  PubMed  Google Scholar 

Gao XH, Zhang GY, Wang Y, Zhang HY. Correlations of MTHFR 677C.T polymorphism with cardiovascular disease in patients with end-stage renal disease: a meta-analysis. PLoS ONE. 2014;9(7):e102323. https://doi.org/10.1371/journal.pone.0102323.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutierrez-Amavizca BE, Orozco-Castellanos R, Ortíz-Orozco R, Padilla-Gutierrez P, Valle Y, Gutierrez-Gutierrez N, Garcia-Garcia G, Gallegos-Arreola M, Figuera LE. Contribution of GSTM1, GSTT1, and MTHFR polymorphisms to end-stage renal disease of unknown etiology in Mexicans. Indian J Nephrol. 2013;23(6):438–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Y, Fan Z, Zhang J, Zhang Q, Zheng M, Li Y, Zhang D, Gu S, Yang H. Polymorphism of eNOS gene association with diabetic nephropathy: a meta-analysis. Mutagenesis. 2011;26(2):339–49.

Article  CAS  PubMed  Google Scholar 

Hishida A, Okada R, Guang Y, Naito M, Wakai K, Hosono S, Nakamura K, Turin TC, Suzuki S, Niimura H, Mikami H, Otonari J, Kuriyama N, Katsuura S, Kubo M, Tanaka H, Hamaiima N. MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC study. Int Urol Nephrol. 2013;45(6):1613–20.

Article  CAS  PubMed  Google Scholar 

Jamison RL, Shih MC, Humphries DE, GuarinoDP KJS, Goldfarb DS, Warren SR, Gaziano JM, Lavori P. Effect of the MTHFR C677T and A1298C polymorphisms on survival in patients with advanced CKD and ESRD: a prospective study. Am J Kidney Dis. 2009;53(5):779–89.

Article  CAS  PubMed  Google Scholar 

Jayapalan JJ, Muniandy S, Pheng CS. Null association between ACE gene I/D polymorphism and diabetic nephropathy among multiethnic Malaysian subjects. Trop J Pharm Res. 2010;9(5):431–9.

CAS  Google Scholar 

Kazancioğlu R. Risk factors for chronic kidney disease: an update. Kidney Int Suppl. 2013;3(4):368–71. https://doi.org/10.1038/kisup.2013.79.

Article  Google Scholar 

Kundal BR, Jasrotia R, Raina JK, Bhardawaj R, Panjaliya RK, Kumar P. Angiotensin converting enzyme (ACE) I/D gene polymorphism in susceptibility of migraine. Indian J Appl Res. 2016;6(6):57–9.

Google Scholar 

Lakkakula BV, Khare RL, Verma HK, Pattnaik S. Genetic association of ACE gene I/D polymorphism with the risk of diabetic kidney disease; a meta-analysis. J Nephropathol. 2019;8(4):e44–e44.

Article  Google Scholar 

Lee JE, Bae SY, Kim JY, Pyo HJ, Kwon YJ. Aldosterone Synthase Gene (CYP11B2) Polymorphism in Korean End-Stage Renal Disease Patients on Hemodialysis. Electrolyte Blood Press. 2009;7:67–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin C, Yang HY, Wu CC, Lee HS, Lin YH, Lu KC, Chu CM, Lin FH, Kao SY, Su SL. Angiotensin-converting enzyme insertion/deletionpolymorphism contributes high risk for chronic kidney disease in asian male with hypertension–a meta-regression analysis of 98 observational studies. PLoS ONE. 2014;9(1):1–16.

Article  Google Scholar 

Lovati E, Richard A, Frey BM, Frey FJ, Ferrari P. Genetic polymorphisms of the renin-angiotensin-aldosterone system in end-stage renal disease. Kidney Int. 2001;60:46–54.

Article  CAS  PubMed  Google Scholar 

Mehmetoglu I, Yilmaz G, Kurban S, Acar H, Duzenli MA. Investigation of eNOS gene intron 4 A/B VNTR and intron 23 polymorphisms in patients with essential hypertension. Turk J Med Sci. 2010;40(3):479–84.

CAS  Google Scholar 

Movvaa S, Alluric RV, Komandurc S, Vattamc K, Eppac K, Mukkavalid KK, Mubigondab S, Sahariab S, Shastryd JC, Hasana Q. Relationship of angiotensin-converting enzyme gene polymorphism with nephropathy associated with type 2 diabetes mellitus in Asian Indians. J Diabetes Complicat. 2007;21:237–41.

Article  Google Scholar 

Mtiraoui N, Ezzidi I, Chaieb M, Marmouche H, Aouni Z, Chaieb A, Mahjoub T, Vaxillaire M, Almawi WY. MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2007;75(1):99–106.

Article  CAS  PubMed  Google Scholar 

Nagamani S, Perumal MS, Perumal RLS, Kesavan C, Muthusamy K. ACE DD genotype associated with females chronic kidney diseases patient of Tamilnadu population. Egyptian J Med Genet. 2015;16:29–33.

Article