Ale-Agha N, Jakobs P, Goy C, Zurek M, Rosen J, Dyballa-Rukes N, Metzger S, Greulich J, von Ameln F, Eckermann O, Unfried K, Brack F, Grandoch M, Thielmann M, Kamler M, Gedik N, Kleinbongard P, Heinen A, Heusch G, Gödecke A, Altschmied J, Haendeler J (2021) Mitochondrial telomerase reverse transcriptase protects from myocardial ischemia/reperfusion injury by improving complex I composition and function. Circulation 144:1876–1890. https://doi.org/10.1161/CIRCULATIONAHA.120.051923

Article  CAS  PubMed  Google Scholar 

Andreadou I, Bell RM, Bøtker HE, Zuurbier CJ (2020) SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models. Biochim Biophys Acta Mol Basis Dis. https://doi.org/10.1016/j.bbadis.2020.165770,16577010.1016/j.bbadis.2020.165770

Article  PubMed  Google Scholar 

Anto Michel N, Ljubojevic-Holzer S, Bugger H, Zirlik A (2022) Cellular heterogeneity of the heart. Front Cardiovasc Med 9: 868466 doi:https://doi.org/10.3389/fcvm.2022.868466

Billah M, Ridiandries A, Rayner BS, Allahwala UK, Dona A, Khachigian LM, Bhindi R (2019) Egr-1 functions as a master switch regulator of remote ischemic preconditioning-induced cardioprotection. Basic Res Cardiol 115:3. https://doi.org/10.1007/s00395-019-0763-9

Article  CAS  PubMed  Google Scholar 

Boengler K, Buechert A, Heinen Y, Roeskes C, Hilfiker-Kleiner D, Heusch G, Schulz R (2008) Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res, 102: 131-135. doi: https://doi.org/10.1161/CIRCRESAHA.107.164699

Boengler K, Hilfiker-Kleiner D, Drexler H, Heusch G, Schulz R (2008) The myocardial JAK/STAT pathway: from protection to failure. Pharmacol Ther 120:172–185. https://doi.org/10.1016/j.pharmthera.2008.08.002

Article  CAS  PubMed  Google Scholar 

Boengler K, Hilfiker-Kleiner D, Heusch G, Schulz R (2010) Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion. Basic Res Cardiol 105:771–785. https://doi.org/10.1007/s00395-010-0124-1

Article  CAS  PubMed Central  PubMed  Google Scholar 

Boengler K, Lochnit G, Schulz R (2018) Mitochondria “THE” target of myocardial conditioning. Am J Physiol Heart Circ Physiol 315:H1215–H1231. https://doi.org/10.1152/ajpheart.00124.2018

Article  PubMed  Google Scholar 

Boengler K, Stahlhofen S, van de Sand A, Gres P, Ruiz-Meana M, Garcia-Dorado D, Heusch G, Schulz R (2009) Presence of connexin 43 in subsarcolemmal but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol 104:141–147. https://doi.org/10.1007/s00395-009-0007-5

Article  CAS  PubMed  Google Scholar 

Boengler K, Ungefug E, Heusch G, Schulz R (2013) The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Curr Pharm Des 19:6890–6895

Article  CAS  PubMed  Google Scholar 

Bolli R, Stein AB, Guo Y, Wang OL, Rokosh G, Dawn B, Molkentin JD, Sanganalmath SK, Zhu Y, Xuan YT (2011) A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning. J Mol Cell Cardiol 50:589–597. https://doi.org/10.1016/j.yjmcc.2011.01.002

Article  CAS  PubMed  Google Scholar 

Bonora M, Wieckowski MR, Sinclair DA, Kroemer G, Pinton P, Galluzzi L (2019) Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nat Rev Cardiol 16:33–55. https://doi.org/10.1038/s41569-018-0074-0

Article  CAS  PubMed Central  PubMed  Google Scholar 

Bøtker HE, Kharbanda R, Schmidt MR, Bøttcher M, Kaltoft AK, Terkelsen CJ, Munk K, Andersen NH, Hansen TM, Trautner S, Lassen JF, Christiansen EH, Krusell LR, Kristensen SD, Thuesen L, Nielsen SS, Rehling M, Sorensen HT, Redington AN, Nielsen TT (2010) Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. Lancet 375:727–734. https://doi.org/10.1016/S0140-6736(09)62001-8

Article  PubMed  Google Scholar 

Butterbach K, Beckmann L, de Sanjose S, Benavente Y, Becker N, Foretova L, Maynadie M, Cocco P, Staines A, Boffetta P, Brennan P, Nieters A (2011) Association of JAK-STAT pathway related genes with lymphoma risk: results of a European case-control study (EpiLymph). Br J Haematol 153:318–333. https://doi.org/10.1111/j.1365-2141.2011.08632.x

Article  CAS  PubMed  Google Scholar 

Candilio L, Malik A, Ariti C, Barnard M, Di Salvo C, Lawrence D, Hayward M, Yap J, Roberts N, Sheikh A, Kolvekar S, Hausenloy DJ, Yellon DM (2015) Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing cardiac bypass surgery: a randomised controlled clinical trial. Heart 10:185–192. https://doi.org/10.1136/heartjnl-2014-306178

Article  Google Scholar 

Chandra Shekar K, Yannopoulos D, Kosmopoulos M, Riess ML (2022) Differential effects of reperfusion on cardiac mitochondrial subpopulations in a preclinical porcine model of acute myocardial infarction. Front Cell Dev Biol 10:843733. https://doi.org/10.3389/fcell.2022.843733

Article  PubMed Central  PubMed  Google Scholar 

Chen H, Jing XY, Shen YJ, Wang TL, Ou C, Lu SF, Cai Y, Li Q, Chen X, Ding YJ, Yu XC, Zhu BM (2018) Stat5-dependent cardioprotection in late remote ischaemia preconditioning. Cardiovasc Res 114:679–689. https://doi.org/10.1093/cvr/cvy014

Article  CAS  PubMed  Google Scholar 

Chen S, Wang Q, Christodoulou A, Mylonas N, Bakker D, Nederlof R, Hollmann MW, Weber NC, Coronel R, Wakker V, Christoffels VM, Andreadou I, Zuurbier CJ (2023) Sodium glucose cotransporter-2 inhibitor empagliflozin reduces infarct size independently of sodium glucose cotransporter-2. Circulation 147:276–279. https://doi.org/10.1161/CIRCULATIONAHA.122.061688

Article  CAS  PubMed  Google Scholar 

Chen ZR, Hong Y, Wen SH, Zhan YQ, Huang WQ (2023) Dexmedetomidine pretreatment protects against myocardial ischemia/reperfusion injury by activating STAT3 signaling. Anesth Analg 137:426–439. https://doi.org/10.1213/ANE.0000000000006487

Article  CAS  PubMed Central  PubMed  Google Scholar 

Cohen MV, Downey JM (2007) Cardioprotection: spotlight on PKG. Br J Pharmacol 152:833–834. https://doi.org/10.1038/sj.bjp.0707453

Article  CAS  PubMed Central  PubMed  Google Scholar 

Comita S, Femmino S, Thairi C, Alloatti G, Boengler K, Pagliaro P, Penna C (2021) Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function. Basic Res Cardiol 116:56. https://doi.org/10.1007/s00395-021-00898-0

Article  CAS  PubMed Central  PubMed  Google Scholar 

Domingos AE, Seara FAC, Oliveira DF, Maciel L, Barbosa RAQ, Barcellos LC, Pinto VS, Fortunato RS, Nascimento JHM (2023) Mitochondrial dysfunction and cardiac ischemia/reperfusion injury are attenuated by nandrolone: role of JAK-STAT3 pathway. Steroids 197:109247. https://doi.org/10.1016/j.steroids.2023.109247

Article  CAS  PubMed  Google Scholar 

Eitel I, Stiermaier T, Rommel KP, Fuernau G, Sandri M, Mangner N, Linke A, Erbs S, Lurz P, Boudriot E, Mende M, Desch S, Schuler G, Thiele H (2015) Cardioprotection by combined intrahospital remote ischaemic perconditioning and postconditioning in ST-elevation myocardial infarction: the randomized LIPSIA CONDITIONING trial. Eur Heart J 36:3049–3057. https://doi.org/10.1093/eurheartj/ehv463

Article  PubMed  Google Scholar 

Ferdinandy P, Andreadou I, Baxter GF, Bøtker HE, Davidson SM, Dobrev D, Gersh BJ, Heusch G, Lecour S, Ruiz-Meana M, Zuurbier CJ, Hausenloy DJ, Schulz R (2023) Interaction of cardiovascular nonmodifiable risk factors, comorbidities and comedications with ischemia/reperfusion injury and cardioprotection by pharmacological treatments and ischemic conditioning. Pharmacol Rev 75:159–216. https://doi.org/10.1124/pharmrev.121.000348

Article  CAS  PubMed Central  PubMed  Google Scholar 

Ferrari R, Pedersini P, Bongrazio M, Gaia G, Bernocchi P, Di Lisa F, Visioli O (1993) Mitochondrial energy production and cation control in myocardial ischaemia and reperfusion. Basic Res Cardiol 88:495–512. https://doi.org/10.1007/BF00795415

Article  CAS  PubMed  Google Scholar 

Fischer P, Hilfiker-Kleiner D (2007) Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis. Basic Res Cardiol 102:393–411. https://doi.org/10.1007/s00395-007-0658-z

Article  PubMed  Google Scholar 

Fuglesteg BN, Suleman N, Tiron C, Kanhema T, Lacerda L, Andreasen TV, Sack MN, Jonassen AK, Mjos OD, Opie LH, Lecour S (2008) Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion. Basic Res Cardiol 103:444–453. https://doi.org/10.1007/s00395-008-0728-x

Article  CAS  PubMed Central  PubMed  Google Scholar 

Garcia-Ropero A, Santos-Gallego CG, Badimon JJ (2019) The anti-inflammatory effects of SGLT inhibitors. Aging (Albany NY) 11:5866–5867. https://doi.org/10.18632/aging.102175

Article  CAS  PubMed  Google Scholar 

Gaspar A, Lourenco AP, Pereira MA, Azevedo P, Roncon-Albuquerque R Jr, Marques J, Leite-Moreira AF (2018) Randomized controlled trial of remote ischaemic conditioning in ST-elevation myocardial infarction as adjuvant to primary angioplasty (RIC-STEMI). Basic Res Cardiol 113:14. https://doi.org/10.1007/s00395-018-0672-3

Article  PubMed  Google Scholar 

Gent S, Skyschally A, Kleinbongard P, Heusch G (2017) lschemic preconditioning in pigs: a causal role for signal transducer and activator of transcription 3. Am J Physiol Heart Circ Physiol 312:H478–H484. https://doi.org/10.1152/ajpheart.00749.2016

Article  PubMed  Google Scholar 

Goodman MD, Koch SE, Afzal MR, Butler KL (2011) STAT subtype specificity and ischemic preconditioning in mice: is STAT-3 enough? Am J Physiol Heart Circ Physiol 300:H522–H526. https://doi.org/10.1152/ajpheart.00231.2010

Article  CAS  PubMed  Google Scholar 

Gustafsson AB, Gottlieb RA (2008) Heart mitochondria: gates of life and death. Cardiovasc Res 77:334–343. https://doi.org/10.1093/cvr/cvm005