Dubberke ER, Olsen MA. Burden of Clostridium difficile on the healthcare system. Clin Infect Dis. 2012;55(Suppl_2):S88-92.

Article  PubMed  PubMed Central  Google Scholar 

McGlone SM, Bailey RR, Zimmer SM, Popovich MJ, Tian Y, Ufberg P, et al. The economic burden of Clostridium difficile. Clin Microbiol Infect. 2012;18(3):282–9.

Article  CAS  PubMed  Google Scholar 

Borren NZ, Ghadermarzi S, Hutfless S, Ananthakrishnan AN. The emergence of Clostridium difficile infection in Asia: a systematic review and meta-analysis of incidence and impact. PLoS ONE. 2017;12(5): e0176797.

Article  PubMed  PubMed Central  Google Scholar 

Reveles KR, Pugh MJV, Lawson KA, Mortensen EM, Koeller JM, Argamany JR, et al. Shift to community-onset Clostridium difficile infection in the national Veterans Health Administration, 2003–2014. Am J Infect Control. 2018;46(4):431–5.

Article  PubMed  Google Scholar 

Fellmeth G, Yarlagadda S, Iyer S. Epidemiology of community-onset Clostridium difficile infection in a community in the South of England. J Infect Public Health. 2010;3(3):118–23.

Article  PubMed  Google Scholar 

McDonald LC, Coignard B, Dubberke E, Song X, Horan T, Kutty PK, et al. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol. 2007;28(2):140–5.

Article  PubMed  Google Scholar 

Gupta A, Khanna S. Community-acquired Clostridium difficile infection: an increasing public health threat. Infect Drug Resist. 2014;7:63–72.

PubMed  PubMed Central  Google Scholar 

Khanna S, Pardi DS, Aronson SL, Kammer PP, Orenstein R, St. Sauver JL, et al. The epidemiology of community-acquired Clostridium difficile infection: a population-based study. Am J Gastroenterol. 2012;107(1):89–95.

Article  PubMed  Google Scholar 

Kuntz JL, Chrischilles EA, Pendergast JF, Herwaldt LA, Polgreen PM. Incidence of and risk factors for community-associated Clostridium difficile infection: a nested case-control study. BMC Infect Dis. 2011;11(1):194.

Article  PubMed  PubMed Central  Google Scholar 

Naggie S, Frederick J, Pien BC, Miller BA, Provenzale DT, Goldberg KC, et al. Community-associated Clostridium difficile infection: experience of a veteran affairs medical center in southeastern USA. Infection. 2010;38(4):297–300.

Article  CAS  PubMed  Google Scholar 

Juneau C, Mendias EP, Wagal N, Loeffelholz M, Savidge T, Croisant S, et al. Community-acquired Clostridium difficile infection: awareness and clinical implications. J Nurse Pract. 2013;9(1):1–6.

Article  PubMed  PubMed Central  Google Scholar 

Mora-Pinzon MC, Buie R, Liou J, Shirley DK, Evans CT, Ramanathan S, et al. Outcomes of community and healthcare-onset Clostridium difficile infections. Clin Infect Dis. 2019;68(8):1343–50.

Article  PubMed  Google Scholar 

Bloomfield LE, Riley TV. Epidemiology and risk factors for community-associated Clostridium difficile infection: a narrative review. Infect Dis Ther. 2016;5(3):231–51.

Article  PubMed  PubMed Central  Google Scholar 

Ochoa-Hein E, Rajme-López S, Rodríguez-Aldama JC, Huertas-Jiménez MA, Chávez-Ríos AR, de Paz-García R, et al. Substantial reduction of healthcare facility-onset Clostridioides difficile infection (HO-CDI) rates after conversion of a hospital for exclusive treatment of COVID-19 patients. Am J Infect Control. 2021;49(7):966–8.

Article  CAS  PubMed  Google Scholar 

Birkmeyer JD, Barnato A, Birkmeyer N, Bessler R, Skinner J. The impact of the COVID-19 pandemic on hospital admissions in the United States. Health Aff. 2020;39(11):2010–7.

Article  Google Scholar 

Khanna S, Kraft CS. The interplay of SARS-CoV-2 and Clostridioides difficile infection. Future Microbiol. 2021;16(6):439–43.

Article  CAS  PubMed  Google Scholar 

Luo Y, Grinspan LT, Fu Y, Adams-Sommer V, Willey DK, Patel G, et al. Hospital-onset Clostridioides difficile infections during the COVID-19 pandemic. Infect Control Hosp Epidemiol. 2021;42(9):1165–6.

Article  PubMed  Google Scholar 

Chen Y, Chen L, Deng Q, Zhang G, Wu K, Ni L, et al. The presence of SARS-CoV-2 RNA in the feces of COVID-19 patients. J Med Virol. 2020;92(7):833–40.

Article  CAS  PubMed  Google Scholar 

Sandhu A, Tillotson G, Polistico J, Salimnia H, Cranis M, Moshos J, et al. Clostridioides difficile in COVID-19 patients, Detroit, Michigan, USA, March–April 2020. Emerg Infect Dis. 2020;26(9):2272–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewandowski K, Rosołowski M, Kaniewska M, Kucha P, Meler A, Wierzba W, et al. Clostridioides difficile infection in coronavirus disease 2019: an underestimated problem? Pol Arch Intern Med. 2020;131(2):121–7.

PubMed  Google Scholar 

Baccolini V, Migliara G, Isonne C, Dorelli B, Barone LC, Giannini D, et al. The impact of the COVID-19 pandemic on healthcare-associated infections in intensive care unit patients: a retrospective cohort study. Antimicrob Resist Infect Control. 2021;10(1):87.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, et al. Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology. 2020;159(3):944-55.e8.

Article  CAS  PubMed  Google Scholar 

Spigaglia P. Clostridioides difficile infection (CDI) during the COVID-19 pandemic. Anaerobe. 2022;1(74): 102518.

Article  Google Scholar 

Knight GM, Glover RE, McQuaid CF, Olaru ID, Gallandat K, Leclerc QJ, et al. Antimicrobial resistance and COVID-19: intersections and implications. Elife. 2021;10: e64139.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tedijanto C, Olesen SW, Grad YH, Lipsitch M. Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora. Proc Natl Acad Sci USA. 2018;115(51):E11988–95.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ul Mustafa Z, Salman M, Aldeyab M, Kow CS, Hasan SS. Antimicrobial consumption among hospitalized patients with COVID-19 in Pakistan. SN Compr Clin Med. 2021;3(8):1691–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grau S, Hernández S, Echeverría-Esnal D, Almendral A, Ferrer R, Limón E, et al. Antimicrobial consumption among 66 acute care hospitals in Catalonia: impact of the COVID-19 pandemic. Antibiotics. 2021;10(8):943.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55–71.

Article  CAS  PubMed  Google Scholar 

Britton RA, Young VB. Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance. Trends Microbiol. 2012;20(7):313–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Winston JA, Theriot CM. Impact of microbial derived secondary bile acids on colonization resistance against Clostridium difficile in the gastrointestinal tract. Anaerobe. 2016;1(41):44–50.

Article  Google Scholar 

Buffie CG, Bucci V, Stein RR, McKenney PT, Ling L, Gobourne A, et al. Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile. Nature. 2015;517(7533):205–8.

Article  CAS  PubMed  Google Scholar 

Weingarden AR, Chen C, Bobr A, Yao D, Lu Y, Nelson VM, et al. Microbiota transplantation restores normal fecal bile acid composition in recurrent Clostridium difficile infection. Am J Physiol Gastrointest Liver Physiol. 2014;306(4):G310–9.

Article  CAS  PubMed  Google Scholar 

Vollaard EJ, Clasener HA. Colonization resistance. Antimicrob Agents Chemother. 1994;38(3):409–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

DePestel DD, Aronoff DM. Epidemiology of Clostridium difficile Infection. J Pharm Pract. 2013;26(5):464–75.

Article  PubMed  PubMed Central  Google Scholar 

Cohen SH, Gerding DN, Johnson S, Kelly CP, Loo VG, McDonald LC, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31(5):431–55.

Article  PubMed  Google Scholar 

Chopra T, Alangaden GJ, Chandrasekar P. Clostridium difficile infection in cancer patients and hematopoietic stem cell transplant recipients. Expert Rev Anti Infect Ther. 2010;8(10):1113–9.

Article  PubMed  Google Scholar 

Garey KW, Sethi S, Yadav Y, DuPont HL. Meta-analysis to assess risk factors for recurrent Clostridium difficile infection. J Hosp Infect. 2008;70(4):298–304.

Article  CAS  PubMed