An update on microRNA as a potential blood-based biomarker for Alzheimer’s disease

Abdelfattah AM, Park C, Choi MY. Update on non-canonical microRNAs. Biomol Concepts. 2014;5(4):275.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abuelezz NZ, Nasr FE, AbdulKader MA, Bassiouny AR, Zaky A. MicroRNAs as potential orchestrators of Alzheimer’s disease-related pathologies: insights on current status and future possibilities. Front Aging Neurosci. 2021;13: 743573.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ashrafian H, Zadeh EH, Khan RH. Review on Alzheimer’s disease: Inhibition of amyloid beta and tau tangle formation. Int J Biol Macromol. 2021;167:382–94.

Article  CAS  PubMed  Google Scholar 

Atkinson AJ, Colburn WA, DeGruttola VG, DeMets DL, Downing GJ, Hoth DF, Oates JA, Peck CC, Schooley RT, Spilker BA, Woodcock J, Zeger SL. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69(3):89–95.

Article  Google Scholar 

Bjerke M, Engelborghs S. Cerebrospinal fluid biomarkers for early and differential Alzheimer’s disease diagnosis. J Alzheimer’s Dis. 2018;62:1199–209.

Article  Google Scholar 

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, de Felice FG. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers. J Clin Invest. 2012;122(4):1339–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Y, Tan X, Lu Q, Huang K, Tang X, He Z. MiR-29c-3p may promote the progression of Alzheimer’s disease through BACE1. J Healthc Eng. 2021;2021:2031407.

Article  PubMed  PubMed Central  Google Scholar 

Carrettiero DC, Hernandez I, Neveu P, Papagiannakopoulos T, Kosik KS. The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule. J Neurosci. 2009;29(7):2151–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Liang H, Zhang J, Zen K, Zhang CY. Horizontal transfer of microRNAs: molecular mechanisms and clinical applications. Prot Cell. 2012;3(1):28–37.

Article  CAS  Google Scholar 

Cho E, Park JY. Emerging roles of 14-3-3γ in the brain disorder. BMB Rep. 2020;53(10):500.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dakterzada F, David Benítez I, Targa A, Lladó A, Torres G, Romero L, de Gonzalo-Calvo D, Moncusí-Moix A, Tort-Merino A, Huerto R, Sánchez-de-la-Torre M, Barbé F, Piñol-Ripoll G. Reduced levels of miR-342-5p in plasma are associated with worse cognitive evolution in patients with mild Alzheimer’s disease. Front Aging Neurosci. 2021;13: 705989.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Felice FG, Vieira MNN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL. Protection of synapses against Alzheimer’s-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers. Proc Natl Acad Sci USA. 2009;106(6):1971–6.

Article  PubMed  PubMed Central  Google Scholar 

Delacourte A, David JP, Sergeant N, Buée L, Wattez A, Vermersch P, Ghozali F, Fallet-Bianco C, Pasquier F, Lebert F, Petit H, di Menza C. The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease. Neurolog. 1999;52(6):1158–1158.

Article  CAS  Google Scholar 

Delay C, Calon F, Mathews P, Hébert SS. Alzheimer-specific variants in the 3’UTR of Amyloid precursor protein affect microRNA function. Mol Neurodegener. 2011;6(1):1–6.

Article  Google Scholar 

Delay C, Hébert SS. MicroRNAs and Alzheimer’s disease mouse models: current insights and future research avenues. Int J Alzheimers Dis. 2011;2011: 894938.

PubMed  PubMed Central  Google Scholar 

El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018;136(4):537–55.

Article  PubMed  PubMed Central  Google Scholar 

FDA Permits Marketing for New Test to Improve Diagnosis of Alzheimer’s Disease | FDA [Internet]. [cited 2022 Jun 21]. https://www.fda.gov/news-events/press-announcements/fda-permits-marketing-new-test-improve-diagnosis-alzheimers-disease

Friedman RC, Farh KKH, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geng L, Zhang T, Liu W, Chen Y. Inhibition of miR-128 abates Aβ-mediated cytotoxicity by targeting PPAR-γ via NF-κB inactivation in primary mouse cortical neurons and Neuro2a cells. Yonsei Med J. 2018;59(9):1096.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghafouri-Fard S, Shoorei H, Bahroudi Z, Abak A, Majidpoor J, Taheri M. An update on the role of miR-124 in the pathogenesis of human disorders. Biomed Pharmacother. 2021;135:1.

Article  Google Scholar 

Guo R, Fan G, Zhang J, Wu C, Du Y, Ye H, Li Z, Wang L, Zhang Z, Zhang L, Zhao Y, Lu Z. A 9-microRNA signature in serum serves as a noninvasive biomarker in early diagnosis of Alzheimer’s disease. J Alzheimers Dis. 2017;60(4):1365–77.

Article  CAS  PubMed  Google Scholar 

Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, de Strooper B. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet. 2010;19(20):3959–69.

Article  PubMed  Google Scholar 

Hernández F, Cuadros R, Avila J. Zeta 14-3-3 protein favours the formation of human tau fibrillar polymers. Neurosci Lett. 2004;357(2):143–6.

Article  PubMed  Google Scholar 

Higaki S, Muramatsu M, Matsuda A, Matsumoto K, Satoh J, Michikawa M, Niida S. Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer’s disease models. PLoS One 2018;13(5):e0196929.

Hippius H, Neundörfer G. The discovery of Alzheimer’s disease. Dialogues Clin Neurosci. 2003;5(1):101.

Article  PubMed  PubMed Central  Google Scholar 

Hung ASM, Liang Y, Chow TCH, Tang HC, Wu SLY, Wai MSM, Yew DT. Mutated tau, amyloid and neuroinflammation in Alzheimer disease—a brief review. Prog Histochem Cytochem. 2016;51(1):1–8.

Article  CAS  PubMed  Google Scholar 

Inestrosa NC, Tapia-Rojas C, Griffith TN, Carvajal FJ, Benito MJ, Rivera-Dictter A, Alvarez AR, Serrano FG, Hancke JL, Burgos PV, Parodi J, Varela-Nallar L. Tetrahydrohyperforin prevents cognitive deficit, Aβ deposition, tau phosphorylation and synaptotoxicity in the APPswe/PSEN1ΔE9 model of Alzheimer’s disease: a possible effect on APP processing. Transl Psychiatry. 2011;1(7):e20.

Jiang H, Liu J, Guo S, Zeng L, Cai Z, Zhang J, Wang L, Li Z, Liu R. miR-23b-3p rescues cognition in Alzheimer’s disease by reducing tau phosphorylation and apoptosis via GSK-3β signaling pathways. Mol Ther Nucl Acids. 2022;28:539–57.

Article  CAS  Google Scholar 

Joo Y, Schumacher B, Landrieu I, Bartel M, Smet-Nocca C, Jang A, Choi HS, Jeon NL, Chang KA, Kim HS, Ottmann C, Suh YH. Involvement of 14-3-3 in tubulin instability and impaired axon development is mediated by Tau. FASEB J. 2015;29(10):4133–44.

Article  CAS  PubMed  Google Scholar 

Khoury R, Ghossoub E. Diagnostic biomarkers of Alzheimer’s disease: A state-of-the-art review. Biomark Neuropsychiatry. 2019;1: 100005.

Article  Google Scholar 

Kumar S, Reddy PH. Are circulating microRNAs peripheral biomarkers for Alzheimer’s disease? Biochim Biophys Acta. 2016;1862(9):1617–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar S, Reddy PH. The role of synaptic microRNAs in Alzheimer’s disease. Biochim Biophys Acta Mol Basis Dis. 2020;1866(12).

Kurt MA, Davies DC, Kidd M, Duff K, Howlett DR. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol Dis. 2003;14(1):89–97.

Article  CAS  PubMed  Google Scholar 

Lee RC, Feinbaum RL, Ambrost V. The C. elegans Heterochronic Gene lin-4 Encodes Small RNAs with Antisense Complementarity to &II-14. Cell. 1993;75:843–54.

Liu Y, Zhang Y, Liu P, Bai H, Li X, Xiao J, Yuan Q, Geng S, Yin H, Zhang H, Wang Z, Li J, Wang S, Wang Y. MicroRNA-128 knockout inhibits the development of Alzheimer’s disease by targeting PPARγ in mouse models. Eur J Pharmacol. 2019;843:134–44.

Article  CAS  PubMed  Google Scholar 

Long JM, Maloney B, Rogers JT, Lahiri DK. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease. Mol Psychiatry. 2018;24(3):345–63.

Article  PubMed  PubMed Central  Google Scholar 

Long JM, Ray B, Lahiri DK. MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects. J Biol Chem. 2014;289(8):5184–98.

Article  CAS  PubMed  Google Scholar 

Lu TX, Rothenberg ME. Fundamentals of allergy and immunology MicroRNA. J Allergy Clin Immunol. 2018;141:1202–7.

Article  CAS  PubMed  Google Scholar 

Ma T, Sun X, Sun S, Guo R, Ma X. The study of peripheral blood miR-29a/101 in the diagnosis of Alzheimer’s disease. Chin J Behav Med Brain Sci. 2016;11:1010–4.

Google Scholar 

Miyoshi K, Miyoshi T, Siomi H. Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production. Mol Genet Genomics. 2010;284(2):95–103.

Article  CAS  PubMed 

Comments (0)

No login
gif