Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T (2014) The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol 204:919–929. https://doi.org/10.1083/jcb.201308006
Article CAS PubMed PubMed Central Google Scholar
Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM (2006) Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A 103:10086–10091. https://doi.org/10.1073/pnas.0603615103
Article CAS PubMed PubMed Central Google Scholar
Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Krokidi AT, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG (2020) The role of nonglycolytic glucose metabolism in myocardial recovery upon mechanical unloading and circulatory support in chronic heart failure. Circulation 142:259–274. https://doi.org/10.1161/CIRCULATIONAHA.119.044452
Article CAS PubMed PubMed Central Google Scholar
Balderas E, Eberhardt DR, Lee S, Pleinis JM, Sommakia S, Balynas AM, Yin X, Parker MC, Maguire CT, Cho S, Szulik MW, Bakhtina A, Bia RD, Friederich MW, Locke TM, Van Hove JLK, Drakos SG, Sancak Y, Tristani-Firouzi M, Franklin S, Rodan AR, Chaudhuri D (2022) Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during complex I impairment. Nat Commun 13:2769. https://doi.org/10.1038/s41467-022-30236-4
Article CAS PubMed PubMed Central Google Scholar
Bhat S, Chin A, Shirakabe A, Ikeda Y, Ikeda S, Zhai P, Hsu CP, Sayed D, Abdellatif M, Byun J, Schesing K, Tang F, Tian Y, Babu G, Ralda G, Warren JS, Cho J, Sadoshima J, Oka SI (2019) Recruitment of RNA polymerase II to metabolic gene promoters is inhibited in the failing heart possibly through PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator-1alpha) dysregulation. Circ Heart Fail 12:e005529. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005529
Article CAS PubMed PubMed Central Google Scholar
Borck PC, Guo LW, Plutzky J (2020) BET epigenetic reader proteins in cardiovascular transcriptional programs. Circ Res 126:1190–1208. https://doi.org/10.1161/CIRCRESAHA.120.315929
Article CAS PubMed PubMed Central Google Scholar
Borlak J, Thum T (2003) Hallmarks of ion channel gene expression in end-stage heart failure. FASEB J 17:1592–1608. https://doi.org/10.1096/fj.02-0889com
Article CAS PubMed Google Scholar
Boudina S, Bugger H, Sena S, O’Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED (2009) Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation 119:1272–1283. https://doi.org/10.1161/CIRCULATIONAHA.108.792101
Article CAS PubMed PubMed Central Google Scholar
Buttrick PM, Kaplan M, Leinwand LA, Scheuer J (1994) Alterations in gene expression in the rat heart after chronic pathological and physiological loads. J Mol Cell Cardiol 26:61–67. https://doi.org/10.1006/jmcc.1994.1008
Article CAS PubMed Google Scholar
Chen L, Gong Q, Stice JP, Knowlton AA (2009) Mitochondrial OPA1, apoptosis, and heart failure. Cardiovasc Res 84:91–99. https://doi.org/10.1093/cvr/cvp181
Article CAS PubMed PubMed Central Google Scholar
Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, Cipolat S, Costa V, Casarin A, Gomes LC, Perales-Clemente E, Salviati L, Fernandez-Silva P, Enriquez JA, Scorrano L (2013) Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell 155:160–171. https://doi.org/10.1016/j.cell.2013.08.032
Article CAS PubMed PubMed Central Google Scholar
Cogliati S, Enriquez JA, Scorrano L (2016) Mitochondrial cristae: where beauty meets functionality. Trends Biochem Sci 41:261–273. https://doi.org/10.1016/j.tibs.2016.01.001
Article CAS PubMed Google Scholar
Cung TT, Morel O, Cayla G, Rioufol G, Garcia-Dorado D, Angoulvant D, Bonnefoy-Cudraz E, Guerin P, Elbaz M, Delarche N, Coste P, Vanzetto G, Metge M, Aupetit JF, Jouve B, Motreff P, Tron C, Labeque JN, Steg PG, Cottin Y, Range G, Clerc J, Claeys MJ, Coussement P, Prunier F, Moulin F, Roth O, Belle L, Dubois P, Barragan P, Gilard M, Piot C, Colin P, De Poli F, Morice MC, Ider O, Dubois-Rande JL, Unterseeh T, Le Breton H, Beard T, Blanchard D, Grollier G, Malquarti V, Staat P, Sudre A, Elmer E, Hansson MJ, Bergerot C, Boussaha I, Jossan C, Derumeaux G, Mewton N, Ovize M (2015) Cyclosporine before PCI in patients with acute myocardial infarction. N Engl J Med 373:1021–1031. https://doi.org/10.1056/NEJMoa1505489
Article CAS PubMed Google Scholar
Davis K, Azarcon P, Hickenlooper S, Bia R, Horiuchi E, Szulik MW, Franklin S (2021) The role of demethylases in cardiac development and disease. J Mol Cell Cardiol 158:89–100. https://doi.org/10.1016/j.yjmcc.2021.05.018
Article CAS PubMed Google Scholar
Diakos NA, Selzman CH, Sachse FB, Stehlik J, Kfoury AG, Wever-Pinzon O, Catino A, Alharethi R, Reid BB, Miller DV, Salama M, Zaitsev AV, Shibayama J, Li H, Fang JC, Li DY, Drakos SG (2014) Myocardial atrophy and chronic mechanical unloading of the failing human heart: implications for cardiac assist device-induced myocardial recovery. J Am Coll Cardiol 64:1602–1612. https://doi.org/10.1016/j.jacc.2014.05.073
Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG (2016) Evidence of Glycolysis up-regulation and pyruvate mitochondrial oxidation mismatch during mechanical unloading of the failing human heart: implications for cardiac reloading and conditioning. JACC Basic Transl Sci 1:432–444. https://doi.org/10.1016/j.jacbts.2016.06.009
Article PubMed PubMed Central Google Scholar
Eberhardt DR, Lee SH, Yin X, Balynas AM, Rekate EC, Kraiss JN, Lang MJ, Walsh MA, Streiff ME, Corbin AC, Li Y, Funai K, Sachse FB, Chaudhuri D (2022) EFHD1 ablation inhibits cardiac mitoflash activation and protects cardiomyocytes from ischemia. J Mol Cell Cardiol 167:1–14. https://doi.org/10.1016/j.yjmcc.2022.03.002
Article CAS PubMed Google Scholar
Franklin S, Zhang MJ, Chen H, Paulsson AK, Mitchell-Jordan SA, Li Y, Ping P, Vondriska TM (2011) Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol Cell Proteomics 10(M110):000703. https://doi.org/10.1074/mcp.M110.000703
Franklin S, Chen H, Mitchell-Jordan S, Ren S, Wang Y, Vondriska TM (2012) Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth. Mol Cell Proteomics 11(M111):014258. https://doi.org/10.1074/mcp.M111.014258
Franklin S, Kimball T, Rasmussen TL, Rosa-Garrido M, Chen H, Tran T, Miller MR, Gray R, Jiang S, Ren S, Wang Y, Tucker HO, Vondriska TM (2016) The chromatin-binding protein Smyd1 restricts adult mammalian heart growth. Am J Physiol Heart Circ Physiol 311:H1234–H1247. https://doi.org/10.1152/ajpheart.00235.2016
Article PubMed PubMed Central Google Scholar
Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko GV, Rudka T, Bartoli D, Polishuck RS, Danial NN, De Strooper B, Scorrano L (2006) OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell 126:177–189. https://doi.org/10.1016/j.cell.2006.06.025
Article CAS PubMed Google Scholar
Gibson-Corley KN, Olivier AK, Meyerholz DK (2013) Principles for valid histopathologic scoring in research. Vet Pathol 50:1007–1015. https://doi.org/10.1177/0300985813485099
Article CAS PubMed Google Scholar
Gottlieb PD, Pierce SA, Sims RJ, Yamagishi H, Weihe EK, Harriss JV, Maika SD, Kuziel WA, King HL, Olson EN, Nakagawa O, Srivastava D (2002) Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet 31:25–32. https://doi.org/10.1038/ng866
Article CAS PubMed Google Scholar
Hou T, Zhang R, Jian C, Ding W, Wang Y, Ling S, Ma Q, Hu X, Cheng H, Wang X (2019) NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly. Cell Res 29:754–766. https://doi.org/10.1038/s41422-019-0208-x
Article CAS PubMed PubMed Central Google Scholar
Houser SR, Margulies KB, Murphy AM, Spinale FG, Francis GS, Prabhu SD, Rockman HA, Kass DA, Molkentin JD, Sussman MA, Koch WJ, American Heart Association Council on Basic Cardiovascular Sciences CoCC, Council on Functional G, Translational B (2012) Animal models of heart failure: a scientific statement from the American heart association. Circ Res 111:131–150. https://doi.org/10.1161/RES.0b013e3182582523
Article CAS PubMed Google Scholar
Jang S, Javadov S (2020) OPA1 regulates respiratory supercomplexes assembly: the role of mitochondrial swelling. Mitochondrion 51:30–39. https://doi.org/10.1016/j.mito.2019.11.006
Article CAS PubMed Google Scholar
Javadov S, Jang S, Chapa-Dubocq XR, Khuchua Z, Camara AK (2021) Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role. J Mol Med (Berl) 99:57–73. https://doi.org/10.1007/s00109-020-02004-8
Article CAS PubMed Google Scholar
Jha P, Wang X, Auwerx J (2016) Analysis of mitochondrial respiratory chain supercomplexes using blue native polyacrylamide gel electrophoresis (BN-PAGE). Curr Protoc Mouse Biol 6:1–14. https://doi.org/10.1002/9780470942390.mo150182
Article PubMed PubMed Central Google Scholar
Johnson JM, Ferrara PJ, Verkerke ARP, Coleman CB, Wentzler EJ, Neufer PD, Kew KA, de Castro Bras LE, Funai K (2018) Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome. J Mol Cell Cardiol 121:94–102. https://doi.org/10.1016/j.yjmcc.2018.07.001
Article CAS PubMed PubMed Central Google Scholar
Karamanlidis G, Garcia-Menendez L, Kolwicz SC Jr, Lee CF, Tian R (2014) Promoting PGC-1alpha-driven mitochondrial biogenesis is detrimental in pressure-overloaded mouse hearts. Am J Physiol Heart Circ Physiol 307:H1307-1316. https://doi.org/10.1152/ajpheart.00280.2014
Comments (0)