World Health Organization (2023) https://covid19.who.int/ 

World Health Organization (2021) A clinical case definition of post COVID-19 condition by a Delphi consensus. https://www.who.int/publications-detail-redirect/WHO-2019-nCoV-Post_COVID-19_condition-Clinical_case_definition-2021.1

Blomberg B, Mohn KG, Brokstad KA, Zhou F, Linchausen DW, Hansen BA, Lartey S, Onyango TB, Kuwelker K, Sævik M et al (2021) Long COVID in a prospective cohort of home-isolated patients. Nat Med 27(9):1607–1613. https://doi.org/10.1038/s41591-021-01433-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tran VT, Porcher R, Pane I, Ravaud P (2022) Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort. Nat Commun 13:1812. https://doi.org/10.1038/s41467-022-29513-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carfì A, Bernabei R, Landi F (2022) Persistent symptoms in patients after acute COVID-19. JAMA 324:603–605. https://doi.org/10.1001/jama.2020.12603

Article  CAS  Google Scholar 

Wettschureck N, Strilic B, Offermanns S (2019) Passing the vascular barrier: endothelial signaling processes controlling extravasation. Physiol Rev 99(3):1467–1525. https://doi.org/10.1152/physrev.00037.2018

Article  CAS  PubMed  Google Scholar 

Bonaventura A, Vecchié A, Dagna L, Martinod K, Dixon DL, Van Tassell BW, Dentali F, Montecucco F, Massberg S, Levi M, Abbate A (2021) Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nat Rev Immunol 21(5):319–329. https://doi.org/10.1038/s41577-021-00536-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fogarty H, Townsend L, Morrin H, Ahmad A, Comerford C, Karampini E, Englert H, Byrne M, Bergin C, O’Sullivan JM et al (2021) Persistent endotheliopathy in the pathogenesis of Long COVID syndrome. J Thromb Haemost 19:2546–2553. https://doi.org/10.1111/jth.15490

Article  CAS  PubMed  Google Scholar 

Fan BE, Wong SW, Sum CLL, Lim GH, Leung BP, Tan CW, Ramanathan K, Dalan R, Cheung C, Lim XR et al (2022) Hypercoagulability, endotheliopathy, and inflammation approximating 1 year after recovery: assessing the long-term outcomes in COVID-19 patients. Am J Hematol 97(7):915–923. https://doi.org/10.1002/ajh.26575

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A et al (2020) Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med 383:120–128. https://doi.org/10.1056/NEJMoa2015432

Article  CAS  PubMed  PubMed Central  Google Scholar 

Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA, Ruschitzka F, Moch H et al (2020) Endothelial cell infection and endotheliitis in COVID-19. Lancet 395(10234):1417–1418. https://doi.org/10.1016/S0140-6736(20)30937-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joffre J, Rodriguez L, Matthay ZA, Lloyd E, Fields AT, Bainton RJ, Kurien P, Sil A, Calfee CS, Woodruff PG et al (2022) COVID-19-associated lung microvascular endotheliopathy: a “from the bench” perspective. Am J Respir Crit Care Med 206(8):961–972. https://doi.org/10.1164/rccm.202107-1774OC

Article  CAS  PubMed  Google Scholar 

Liu F, Han K, Blair R, Kenst K, Qin Z, Upcin B, Wörsdörfer P, Midkiff CC, Mudd J, Belyaeva E et al (2021) SARS-CoV-2 infects endothelial cells in vivo and in vitro. Front Cell Infect Microbiol 11:701278. https://doi.org/10.3389/fcimb.2021.701278

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei Y, Zhang J, Schiavon CR, He M, Chen L, Shen H, Zhang Y, Yin Q, Cho Y, Andrade L et al (2021) SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE2. Circ Res 128:1323–1326. https://doi.org/10.1161/CIRCRESAHA.121.318902

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E et al (2021) Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure. Eur Respir J 57:2002384. https://doi.org/10.1183/13993003.02384-2020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrett TJ, Cornwell M, Myndzar K, Rolling CC, Xia Y, Drenkova K, Biebuyck A, Fields AT, Tawil M, Luttrell-Williams E et al (2021) Platelets amplify endotheliopathy in COVID-19. Sci Adv 7:eabh2434. https://doi.org/10.1126/sciadv.abh2434

Article  CAS  PubMed  PubMed Central  Google Scholar 

Noris M, Benigni A, Remuzzi G (2020) The case of complement activation in COVID-19 multiorgan impact. Kidney Int 98(2):314–322. https://doi.org/10.1016/j.kint.2020.05.013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halawa S, Pullamsetti SS, Bangham CRM, Stenmark KR, Dorfmüller P, Frid MG, Butrous G, Morrell NW, de Jesus Perez VA, Stuart DI et al (2022) Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective. Nat Rev Cardiol 19:314–331. https://doi.org/10.1038/s41569-021-00640-2

Article  CAS  PubMed  Google Scholar 

Afzali B, Noris M, Lambrecht BN, Kemper C (2022) The state of complement in COVID-19. Nat Rev Immunol 22(2):77–84. https://doi.org/10.1038/s41577-021-00665-1

Article  CAS  PubMed  Google Scholar 

Dupont A, Rauch A, Staessens S, Moussa M, Rosa M, Corseaux D, Jeanpierre E, Goutay J, Caplan M, Varlet P et al (2021) Vascular endothelial damage in the pathogenesis of organ injury in severe COVID-19. Arterioscler Thromb Vasc Biol 41:1760–1773. https://doi.org/10.1161/ATVBAHA.120.315595

Article  CAS  PubMed  Google Scholar 

Goshua G, Pine AB, Meizlish ML, Chang CH, Zhang H, Bahel P, Baluha A, Bar N, Bona RD, Burns AJ et al (2020) Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study. Lancet Haematol 7(8):e575–e582. https://doi.org/10.1016/S2352-3026(20)30216-7

Article  PubMed  PubMed Central  Google Scholar 

He Z, Si Y, Jiang T, Ma R, Zhang Y, Cao M, Li T, Yao Z, Zhao L, Fang S et al (2016) Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease. Thromb Haemost 115:738–751. https://doi.org/10.1160/TH15-09-0710

Article  PubMed  Google Scholar 

Flaumenhaft R, Enjyoji K, Schmaier AA (2022) Vasculopathy in COVID-19. Blood 140(3):222–235. https://doi.org/10.1182/blood.2021012250

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chioh FW, Fong SW, Young BE, Wu KX, Siau A, Krishnan S, Chan YH, Carissimo G, Teo LL, Gao F et al (2021) Convalescent COVID-19 patients are susceptible to endothelial dysfunction due to persistent immune activation. Elife 10:e64909. https://doi.org/10.7554/eLife.64909

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zanoli L, Gaudio A, Mikhailidis DP, Katsiki N, Castellino N, Lo Cicero L, Geraci G, Sessa C, Fiorito L, Marino F et al (2022) Vascular dysfunction of COVID-19 is partially reverted in the long-term. Circ Res 130(9):1276–1285. https://doi.org/10.1161/CIRCRESAHA.121.320460

Article  CAS  PubMed  Google Scholar 

Lambadiari V, Mitrakou A, Kountouri A, Thymis J, Katogiannis K, Korakas E, Varlamos C, Andreadou I, Tsoumani M, Triantafyllidi H et al (2021) Association of COVID-19 with impaired endothelial glycocalyx, vascular function and myocardial deformation 4 months after infection. Eur J Heart Fail 23(11):1916–1926. https://doi.org/10.1002/ejhf.2326

Article  CAS  PubMed  Google Scholar 

Gaebler C, Wang Z, Lorenzi JCC, Muecksch F, Finkin S, Tokuyama M, Cho A, Jankovic M, Schaefer-Babajew D, Oliveira TY et al (2021) Evolution of antibody immunity to SARS-CoV-2. Nature 591(7851):639–644. https://doi.org/10.1038/s41586-021-03207-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zollner A, Koch R, Jukic A, Pfister A, Meyer M, Rössler A, Kimpel J, Adolph TE, Tilg H et al (2022) Post-acute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases. Gastroenterology 163(2):495–506. https://doi.org/10.1053/j.gastro.2022.04.037

Article  CAS  PubMed  Google Scholar 

Cheung CCL, Goh D, Lim X, Tien TZ, Lim JCT, Lee JN, Tan B, Tay ZEA, Wan WY, Chen EX et al (2022) Residual SARS-CoV-2 viral antigens detected in GI and hepatic tissues from five recovered patients with COVID-19. Gut 71(1):226–229. https://doi.org/10.1136/gutjnl-2021-324280

Article  CAS  PubMed  Google Scholar 

Hu F, Chen F, Ou Z, Fan Q, Tan X, Wang Y, Pan Y, Ke B, Li L, Guan Y et al (2020) A compromised specific humoral immune response against the SARS-CoV-2 receptor-binding domain is related to viral persistence and periodic shedding in the gastrointestinal tract. Cell Mol immunol 17(11):1119–1125. https://doi.org/10.1038/s41423-020-00550-2

Article  CAS  PubMed  Google Scholar 

Neurath MF, Überla K, Ng SC (2021) Gut as viral reservoir: lessons from gut viromes, HIV and COVID-19. Gut 70(9):1605–1608. https://doi.org/10.1136/gutjnl-2021-324622

Article  CAS  PubMed  Google Scholar 

Ayoubkhani D, Bermingham C, Pouwels KB, Glickman M, Nafilyan V, Zaccardi F, Khunti K, Alwan NA, Walker AS (2022) Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study. BMJ 377:e069676. https://doi.org/10.1136/bmj-2021-069676

Article  PubMed  Google Scholar 

Arkin LM, Moon JJ, Tran JM, Asgari S, O’Farrelly C, Casanova JL, Cowen EW, Mays JW, Singh AM, Drolet BA, COVID Human Genetic Effort (2021) From your nose to your toes: a review of severe acute respiratory syndrome coronavirus 2 pandemic-associated pernio. J Invest Dermatol 141(12):2791–2796. https://doi.org/10.1016/j.jid.2021.05.024

Article  CAS