Wang CS, Wang SB. Insect pathogenic fungi: genomics, molecular interactions, and genetic improvements. Annu Rev Entomol. 2017;62:73–90.
Article CAS PubMed Google Scholar
Araújo JP, Hughes DP. Diversity of entomopathogenic fungi: which groups conquered the insect body? Adv Genet. 2016;94:1–39.
Shang Y, Feng P, Wang C. Fungi that infect insects: altering host behavior and beyond. PLoS Pathog. 2015;11:e1005037.
Article PubMed PubMed Central Google Scholar
Vega FE. The use of fungal entomopathogens as endophytes in biological control: a review. Mycologia. 2018;110:4–30.
Shang YF, Xiao GH, Zheng P, et al. Divergent and convergent evolution of fungal pathogenicity. Genome Biol Evol. 2016;8:1374–87. Comparative and phylogenomic analysis show that ascomycete entomopathogenic fungi are more closely related to plant pathogenic fungi than to mammalian pathogens.
Nourrisson C, Dupont D, Lavergne RA, et al. Species of Metarhizium anisopliae complex implicated in human infections: retrospective sequencing study. Clin Microbiol Infect. 2017;23:994–9.
Article CAS PubMed Google Scholar
Ducange P, Verdina T, Stiro F, et al. Beauveria bassiana keratitis: management of an atypical clinical presentation. Med Mycol Case Rep. 2021;33:1–4.
Article PubMed PubMed Central Google Scholar
Tucker DL, Beresford CH, Sigler L, et al. Disseminated Beauveria bassiana infection in a patient with acute lymphoblastic leukemia. J Clin Microbiol. 2004;42:5412–4.
Article CAS PubMed PubMed Central Google Scholar
Vilela R, Mendoza L. Human pathogenic Entomophthorales. Clin Microbiol Rev. 2018;31:e00014–18. This review highlights that Entomophthoralean insect pathogens can infect humans.
Shaikh N, Hussain KA, Petraitiene R, et al. Entomophthoramycosis: a neglected tropical mycosis. Clin Microbiol Infect. 2016;22:688–94.
Article CAS PubMed Google Scholar
Sheehan G, Garvey A, Croke M, et al. Innate humoral immune defences in mammals and insects: the same, with differences? Virulence. 2018;9:1625–39.
Article CAS PubMed PubMed Central Google Scholar
Durieux MF, Melloul É, Jemel S, et al. Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus. Virulence. 2021;12:818–34.
Article CAS PubMed PubMed Central Google Scholar
Lemaitre B, Nicolas E, Michaut L, et al. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 1996;86:973–83.
Article CAS PubMed Google Scholar
Kaczmarek A, Boguś MI. Fungi of entomopathogenic potential in Chytridiomycota and Blastocladiomycota, and in fungal allies of the Oomycota and Microsporidia. IMA Fungus. 2021;12:29.
Article PubMed PubMed Central Google Scholar
Luangsa-Ard J, Tasanathai K, Thanakitpipattana D, et al. Novel and interesting Ophiocordyceps spp. (Ophiocordycipitaceae, Hypocreales) with superficial perithecia from Thailand. Stud Mycol. 2018;89:125–42.
Hu X, Xiao G, Zheng P, et al. Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation. Proc Natl Acad Sci USA. 2014;111:16796–801.
Article CAS PubMed PubMed Central Google Scholar
Sheng H, McNamara PJ, St Leger RJ. Metarhizium: an opportunistic middleman for multitrophic lifestyles. Curr Opin Microbiol. 2022;69:102176.
Li J, Xia Y. Host-pathogen interactions between Metarhizium spp. and locusts. J Fungi. 2022;8:602.
Shang JM, Shang YF, Tang GR, et al. Identification of a key G-protein coupled receptor in mediating appressorium formation and fungal virulence against insects. Sci China Life Sci. 2021;64:466–77. This study reveals that a core GPCR is required for Metarhizium robertsii to recognize different species of insects.
Chen X, Xu C, Qian Y, et al. MAPK cascade-mediated regulation of pathogenicity, conidiation and tolerance to abiotic stresses in the entomopathogenic fungus Metarhizium robertsii. Environ Microbiol. 2016;18:1048–62.
Article CAS PubMed Google Scholar
Tang D, Tang X, Fang W. New downstream signaling branches of the mitogen-activated protein kinase cascades identified in the insect pathogenic and plant symbiotic fungus Metarhizium robertsii. Front Fungal Biol. 2022;3:911366.
Guo N, Qian Y, Zhang Q, et al. Alternative transcription start site selection in Mr-OPY2 controls lifestyle transitions in the fungus Metarhizium robertsii. Nat Commun. 2017;8:1565.
Article PubMed PubMed Central Google Scholar
Lai Y, Cao X, Chen J, et al. Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection. Sci Adv. 2020;6:eaaz1659.
Ying SH, Feng MG. Insight into vital role of autophagy in sustaining biological control potential of fungal pathogens against pest insects and nematodes. Virulence. 2019;10:429–37.
Article CAS PubMed Google Scholar
Duan ZB, Chen YX, Huang W, et al. Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii. Autophagy. 2013;9:538–49.
Article CAS PubMed PubMed Central Google Scholar
Li B, Song S, Wei X, et al. Activation of microlipophagy during early infection of insect hosts by Metarhizium robertsii. Autophagy. 2022;18:608–23.
Article CAS PubMed Google Scholar
Mei L, Wang X, Yin Y, et al. Conservative production of galactosaminogalactan in Metarhizium is responsible for appressorium mucilage production and topical infection of insect hosts. PLoS Pathog. 2021;17:e1009656.
Article CAS PubMed PubMed Central Google Scholar
Mukherjee K, Vilcinskas A. The entomopathogenic fungus Metarhizium robertsii communicates with the insect host Galleria mellonella during infection. Virulence. 2018;9:402–13.
Article PubMed PubMed Central Google Scholar
Garbe E, Vylkova S. Role of amino acid metabolism in the virulence of human pathogenic fungi. Curr Clin Microbiol Rep. 2019;6:108–19.
Gu CX, Zhang BL, Bai WW, et al. Characterization of the endothiapepsin-like protein in the entomopathogenic fungus Beauveria bassiana and its virulence effect on the silkworm, Bombyx mori. J Invertebr Pathol. 2020;169:107277.
Article CAS PubMed Google Scholar
Harris-Tryon TA, Grice EA. Microbiota and maintenance of skin barrier function. Science. 2022;376:940–5.
Article CAS PubMed Google Scholar
Pamer EG. Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens. Science. 2016;352:535–8.
Article CAS PubMed PubMed Central Google Scholar
Ducarmon QR, Zwittink RD, Hornung BVH, et al. Gut microbiota and colonization resistance against bacterial enteric infection. Microbiol Mol Biol Rev. 2019;83:e00007-19.
Article PubMed PubMed Central Google Scholar
Hong S, Sun Y, Sun D, et al. Microbiome assembly on Drosophila body surfaces benefits the flies to combat fungal infections. iScience. 2022;25:104408. This study shows that, similar to human skin microbiotas, the ectomicrobiomes formed on insects can defend against fungal pathogen infections.
Zhou F, Wu X, Xu L, et al. Repressed Beauveria bassiana infections in Delia antiqua due to associated microbiota. Pest Manag Sci. 2019;75:170–9.
Article CAS PubMed Google Scholar
Boucias DG, Zhou Y, Huang S, et al. Microbiota in insect fungal pathology. Appl Microbiol Biotechnol. 2018;102:5873–88.
Article CAS PubMed Google Scholar
Batey SFD, Greco C, Hutchings MI, et al. Chemical warfare between fungus-growing ants and their pathogens. Curr Opin Chem Biol. 2020;59:172–81.
Article CAS PubMed PubMed Central Google Scholar
Pessotti RC, Hansen BL, Reaso JN, et al. Multiple lineages of Streptomyces produce antimicrobials within passalid beetle galleries across eastern North America. Elife. 2021;10:e65091.
Article CAS PubMed PubMed Central Google Scholar
Ren C, Webster P, Finkel SE, et al. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 2007;6:144–52.
Article CAS PubMed Google Scholar
Sun YL, Chen B, Li XL, et al. Orchestrated biosynthesis of the secondary metabolite cocktails enables the producing fungus to combat diverse bacteria. mBio. 2022;13:e0180022.
Zhang L, Yue Q, Wang C, et al. Secondary metabolites from hypocrealean entomopathogenic fungi: genomics as a tool to elucidate the encoded parvome. Nat Prod Rep. 2020;37:1164–80.
Article CAS PubMed PubMed Central Google Scholar
Sun YL, Hong S, Chen HM, et al. Production of helvolic acid in Metarhizium contributes to fungal infection of insects by bacteriostatic inhibition of the host cuticular microbiomes. Microbiol Spectr. 2022;10:e0262022.
Hong S, Sun YL, Chen HM, et al. Suppression of the insect cuticular microbiomes by a fungal defensin to facilitate parasite infection. ISME J. 2022. https://doi.org/10.1038/s41396-022-01323-7.
Li S, Yi W, Chen S, et al. Empirical support for the pattern
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