https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight. Assessed 28 Dec 2024.

Kelly T, Yang W, Chen CS, Reynolds K, He J. Global burden of obesity in 2005 and projections to 2030. Int J Obes (Lond). 2008;32(9):1431–7. https://doi.org/10.1038/ijo.2008.102.

Article  PubMed  CAS  Google Scholar 

Dalamaga M, Nikolaidou A, Karmaniolas K, Hsi A, Chamberland J, Dionyssiou-Asteriou A, Mantzoros CS. Circulating adiponectin and leptin in relation to myelodysplastic syndrome: a case-control study. Oncology. 2007;73(1–2):26–32. https://doi.org/10.1159/000120995.

Article  PubMed  Google Scholar 

Pakhare M, Anjankar A. Critical correlation between obesity and cardiovascular diseases and recent advancements in obesity. Cureus. 2024;16(1):e51681. https://doi.org/10.7759/cureus.51681.

Article  PubMed  PubMed Central  Google Scholar 

Kounatidis D, Vallianou NG, Stratigou T, Voukali M, Karampela I, Dalamaga M. The kidney in obesity: current evidence, perspectives and controversies. Curr Obes Rep. 2024;13(4):680–702. https://doi.org/10.1007/s13679-024-00583-y.

Article  PubMed  Google Scholar 

Tsilingiris D, Vallianou NG, Spyrou N, Kounatidis D, Christodoulatos GS, Karampela I, Dalamaga M. Obesity and leukemia: biological mechanisms, perspectives, and challenges. Curr Obes Rep. 2024;13(1):1–34. https://doi.org/10.1007/s13679-023-00542-z.

Article  PubMed  Google Scholar 

Simati S, Kokkinos A, Dalamaga M, Argyrakopoulou G. Obesity paradox: fact or fiction? Curr Obes Rep. 2023;12(2):75–85. https://doi.org/10.1007/s13679-023-00497-1.

Article  PubMed  Google Scholar 

Strulov Shachar S, Williams GR. The obesity paradox in cancer-moving beyond BMI. Cancer Epidemiol Biomarkers Prev. 2017;26(1):13–6. https://doi.org/10.1158/1055-9965.EPI-16-0439.

Article  PubMed  Google Scholar 

McLean LL, Pellino K, Brewis M, Peacock A, Johnson M, Church AC. The obesity paradox in pulmonary arterial hypertension: the Scottish perspective. ERJ Open Res. 2019;5(4):00241–2019. https://doi.org/10.1183/23120541.00241-2019.

Article  PubMed  PubMed Central  Google Scholar 

Lempesis IG, Liu J, Dalamaga M. The catcher in the gut: tirzepatide, a dual incretin analog for the treatment of type 2 diabetes mellitus and obesity. Metabol Open. 2022;16:100220. https://doi.org/10.1016/j.metop.2022.100220.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahmadian M, Suh JM, Hah N, Liddle C, Atkins AR, Downes M, Evans RM. PPARγ signaling and metabolism: the good, the bad and the future. Nat Med. 2013;19(5):557–66. https://doi.org/10.1038/nm.3159.

Article  PubMed  CAS  Google Scholar 

Chi T, Wang M, Wang X, Yang K, Xie F, Liao Z, Wei P. PPAR-γ modulators as current and potential cancer treatments. Front Oncol. 2021;11:737776. https://doi.org/10.3389/fonc.2021.737776.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang L, Waltenberger B, Pferschy-Wenzig EM, Blunder M, Liu X, Malainer C, Blazevic T, Schwaiger S, Rollinger JM, Heiss EH, Schuster D, Kopp B, Bauer R, Stuppner H, Dirsch VM, Atanasov AG. Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review. Biochem Pharmacol. 2014;92(1):73–89. https://doi.org/10.1016/j.bcp.2014.07.018.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lebovitz HE. Thiazolidinediones: the forgotten diabetes medications. Curr Diab Rep. 2019;19(12):151. https://doi.org/10.1007/s11892-019-1270-y.

Article  PubMed  PubMed Central  Google Scholar 

Vallianou NG, Tsilingiris D, Kounatidis D, Lempesis IG, Karampela I, Dalamaga M. Sodium-glucose cotransporter-2 inhibitors in obesity and associated cardiometabolic disorders: where do we stand? Pol Arch Intern Med. 2022;132(10):16342. https://doi.org/10.20452/pamw.16342.

Article  PubMed  Google Scholar 

Drucker DJ. Efficacy and safety of GLP-1 medicines for type 2 diabetes and obesity. Diabetes Care. 2024;47(11):1873–88. https://doi.org/10.2337/dci24-0003.

Article  PubMed  CAS  Google Scholar 

Cheng HS, Tan WR, Low ZS, Marvalim C, Lee JYH, Tan NS. Exploration and development of PPAR modulators in health and disease: an update of clinical evidence. Int J Mol Sci. 2019;20(20):5055. https://doi.org/10.3390/ijms20205055.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Todaro B, Moscardini A, Luin S. Pioglitazone-loaded PLGA nanoparticles: towards the most reliable synthesis method. Int J Mol Sci. 2022;23(5):2522. https://doi.org/10.3390/ijms23052522.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sarkar C, Das B, Rawat VS, Wahlang JB, Nongpiur A, Tiewsoh I, Lyngdoh NM, Das D, Bidarolli M, Sony HT. Artificial intelligence and machine learning technology driven modern drug discovery and development. Int J Mol Sci. 2023;24(3):2026. https://doi.org/10.3390/ijms24032026.

Article  PubMed  PubMed Central  Google Scholar 

Wang QA, Zhang F, Jiang L, Ye R, An Y, Shao M, Tao C, Gupta RK, Scherer PE. Peroxisome proliferator-activated receptor γ and Its Role in adipocyte homeostasis and thiazolidinedione-mediated insulin sensitization. Mol Cell Biol. 2018;38(10):e00677-e717. https://doi.org/10.1128/MCB.00677-17.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li Z, Luo L, Yu W, Li P, Ou D, Liu J, Ma H, Sun Q, Liang A, Huang C, Chi T, Huang X, Zhang Y. PPARγ phase separates with RXRα at PPREs to regulate target gene expression. Cell Discov. 2022;8(1):37. https://doi.org/10.1038/s41421-022-00388-0.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kononova YA, Tuchina TP, Babenko AY. Brown and beige adipose tissue: one or different targets for treatment of obesity and obesity-related metabolic disorders? Int J Mol Sci. 2024;25(24):13295. https://doi.org/10.3390/ijms252413295.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng L, Wang J, Dai H, Duan Y, An Y, Shi L, Lv Y, Li H, Wang C, Ma Q, Li Y, Li P, Du H, Zhao B. Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte. 2021;10(1):48–65. https://doi.org/10.1080/21623945.2020.1870060.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ziqubu K, Dludla PV, Mthembu SXH, Nkambule BB, Mabhida SE, Jack BU, Nyambuya TM, Mazibuko-Mbeje SE. An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin. Front Endocrinol (Lausanne). 2023;14:1114767. https://doi.org/10.3389/fendo.2023.1114767.

Article  PubMed  Google Scholar 

Ma X, Wang D, Zhao W, Xu L. Deciphering the roles of PPARγ in adipocytes via dynamic change of transcription complex. Front Endocrinol (Lausanne). 2018;9:473. https://doi.org/10.3389/fendo.2018.00473.

Article  PubMed  Google Scholar 

Duszka K, Wahli W. Peroxisome proliferator-activated receptors as molecular links between caloric restriction and circadian rhythm. Nutrients. 2020;12(11):3476. https://doi.org/10.3390/nu12113476.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Luo L, Liu M. Adipose tissue in control of metabolism. J Endocrinol. 2016;231(3):R77–99. https://doi.org/10.1530/JOE-16-0211.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375–91. https://doi.org/10.1152/ajpcell.00379.2020.

Article  PubMed