Oelkrug R, Polymeropoulos ET, Jastroch M. Brown adipose tissue: physiological function and evolutionary significance. J Comp Physiol. 2015;185(6):587–606.

Article  CAS  Google Scholar 

Smith U, Kahn BB. Adipose tissue regulates insulin sensitivity: role of adipogenesis, de novo lipogenesis and novel lipids. J Intern Med. 2016;280(5):465–75.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, et al. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017;542(7642):450–5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ghaben AL, Scherer PE. Adipogenesis and metabolic health. Nat Rev Mol Cell Biol. 2019;20(4):242–58.

Article  PubMed  CAS  Google Scholar 

Kahn CR, Wang G, Lee KY. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J Clin Investig. 2019;129(10):3990–4000.

Article  PubMed  PubMed Central  Google Scholar 

McLaughlin T, Lamendola C, Liu A, Abbasi F. Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity. J Clin Endocrinol Metab. 2011;96(11):E1756-1760.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kumagai N, Morii N, Fujisawa K, Nemoto Y, Narumiya S. ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. J Biol Chem. 1993;268(33):24535–8.

Article  PubMed  CAS  Google Scholar 

Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 2008;7(5):410–20.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Żelechowska P, Brzezińska-Błaszczyk E, Kusowska A, Kozłowska E. The role of adipokines in the modulation of lymphoid lineage cell development and activity: an overview. Obes Rev. 2020;21(10): e13055.

Article  PubMed  Google Scholar 

Fischer J, Völzke H, Kassubek J, Müller HP, Kühn JP, Nauck M, Friedrich N, Zylla S. Associations of a panel of adipokines with fat deposits and metabolic phenotypes in a general population. Obesity (Silver Spring, Md). 2020;28(8):1550–9.

Article  PubMed  CAS  Google Scholar 

Li M, Li C, Liu Y, Chen Y, Wu X, Yu D, Werth VP, Williams KJ, Liu ML. Decreased secretion of adiponectin through its intracellular accumulation in adipose tissue during tobacco smoke exposure. Nutr Metab. 2015;12:15.

Article  Google Scholar 

Hartwig S, De Filippo E, Göddeke S, Knebel B, Kotzka J, Al-Hasani H, Roden M, Lehr S, Sell H. Exosomal proteins constitute an essential part of the human adipose tissue secretome. Biochim Biophys Acta. 2019;1867(12): 140172.

Article  CAS  Google Scholar 

Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487–514.

Article  PubMed  CAS  Google Scholar 

Kranendonk ME, Visseren FL, van Herwaarden JA, Nolte-’t Hoen EN, de Jager W, Wauben MH, Kalkhoven E. Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells. Obesity (Silver Spring, Md). 2014;22(10):2216–23.

Article  PubMed  CAS  Google Scholar 

Müller G, Schneider M, Biemer-Daub G, Wied S. Upregulation of lipid synthesis in small rat adipocytes by microvesicle-associated CD73 from large adipocytes. Obesity (Silver Spring, Md). 2011;19(8):1531–44.

Article  PubMed  Google Scholar 

Sano S, Izumi Y, Yamaguchi T, Yamazaki T, Tanaka M, Shiota M, Osada-Oka M, Nakamura Y, Wei M, Wanibuchi H, et al. Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells. Biochem Biophys Res Commun. 2014;445(2):327–33.

Article  PubMed  CAS  Google Scholar 

Zhou X, Li Z, Qi M, Zhao P, Duan Y, Yang G, Yuan L. Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice. Theranostics. 2020;10(18):8197–210.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Torres S, Fabersani E, Marquez A, Gauffin-Cano P. Adipose tissue inflammation and metabolic syndrome the proactive role of probiotics. Euro J Nut. 2019;58(1):27–43.

Article  Google Scholar 

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Investig. 2003;112(12):1796–808.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab. 2008;8(4):301–9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Deng ZB, Poliakov A, Hardy RW, Clements R, Liu C, Liu Y, Wang J, Xiang X, Zhang S, Zhuang X, et al. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Diabetes. 2009;58(11):2498–505.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kranendonk ME, Visseren FL, van Balkom BW, Nolte-’t Hoen EN, van Herwaarden JA, de Jager W, Schipper HS, Brenkman AB, Verhaar MC, Wauben MH, et al. Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages. Obesity (Silver Spring, Md). 2014;22(5):1296–308.

Article  PubMed  CAS  Google Scholar 

Flaherty SE 3rd, Grijalva A, Xu X, Ables E, Nomani A, Ferrante AW Jr. A lipase-independent pathway of lipid release and immune modulation by adipocytes. Science (New York, NY). 2019;363(6430):989–93.

Article  CAS  Google Scholar 

Matozaki T, Murata Y, Okazawa H, Ohnishi H. Functions and molecular mechanisms of the CD47-SIRPalpha signalling pathway. Trends Cell Biol. 2009;19(2):72–80.

Article  PubMed  CAS  Google Scholar 

Veillette A, Chen J. SIRPα-CD47 immune checkpoint blockade in anticancer therapy. Trends Immunol. 2018;39(3):173–84.

Article  PubMed  CAS  Google Scholar 

Zhang B, Yang Y, Xiang L, Zhao Z, Ye R. Adipose-derived exosomes: a novel adipokine in obesity-associated diabetes. J Cell Physiol. 2019;234(10):16692–702.

Article  PubMed  CAS  Google Scholar 

Monk JM, Liddle DM, Hutchinson AL, Robinson LE. Studying adipocyte and immune cell cross talk using a co-culture system. Methods Mol Biol (Clifton, NJ). 2020;2184:111–30.

Article  CAS  Google Scholar 

Arimochi H, Sasaki Y, Kitamura A, Yasutomo K. Differentiation of preadipocytes and mature adipocytes requires PSMB8. Sci Rep. 2016;6:26791.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao J, Li X, Wang Y, Cao Y, Yao D, Sun L, Qin L, Qiu H, Zhan X. Adipocyte-derived extracellular vesicles modulate appetite and weight through mTOR signalling in the hypothalamus. Acta Physiol (Oxf). 2020;228(2): e13339.

Article  PubMed  CAS  Google Scholar 

Jiang TY, Shi YY, Cui XW, Pan YF, Lin YK, Feng XF, Ding ZW, Yang C, Tan YX, Dong LW, et al. PTEN deficiency facilitates exosome secretion and metastasis in cholangiocarcinoma by impairing TFEB-mediated lysosome biogenesis. Gastroenterology. 2023;164(3):424–38.

Article  PubMed  CAS  Google Scholar 

Thiele M, Suvitaival T, Trošt K, Kim M, de Zawadzki A, Kjaergaard M, Rasmussen DN, Lindvig KP, Israelsen M, Detlefsen S, et al. Sphingolipids are depleted in alcohol-related liver fibrosis. Gastroenterology. 2023;164(7):1248–60.